You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CEPT1
Choline/ethanolaminephosphotransferase 1

Protein Summary
Description
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. This gene codes for a choline/ethanolaminephosphotransferase, which functions in the synthesis of choline- or ethanolamine- containing phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357172
  • ENSP00000349696
  • ENSG00000134255
  • ENST00000545121
  • ENSP00000441980
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.96
transcription factor perturbation
0.84
interacting protein
0.77
disease perturbation
0.68
kinase perturbation
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (105)
RBM6
Tbio
Novelty:  0.06349982
p_int:  0.98782727
p_ni:  0.012170334
p_wrong:  0.000002397
Score:  0.293
Data Source:  BioPlex,STRINGDB
AFDN
Tbio
Novelty:  0.00372947
p_int:  0.931234545
p_ni:  0.06862605
p_wrong:  0.000139405
Score:  0.214
Data Source:  BioPlex,STRINGDB
ARFGAP2
Tbio
Family:  Enzyme
Novelty:  0.08758647
p_int:  0.84445641
p_ni:  0.001967871
p_wrong:  0.153575719
Score:  0.634
Data Source:  BioPlex,STRINGDB
PCYT1B
Tbio
Family:  Enzyme
Novelty:  0.02972878
Score:  0.98
Data Source:  STRINGDB
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
Score:  0.979
Data Source:  STRINGDB
PCYT1A
Tchem
Family:  Enzyme
Novelty:  0.00621528
Score:  0.978
Data Source:  STRINGDB
PISD
Tbio
Family:  Enzyme
Novelty:  0.00966227
Score:  0.967
Data Source:  STRINGDB
MBOAT1
Tdark
Family:  Enzyme
Novelty:  0.05745641
Score:  0.963
Data Source:  STRINGDB
PTDSS2
Tbio
Family:  Enzyme
Novelty:  0.08551192
Score:  0.959
Data Source:  STRINGDB
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
Score:  0.958
Data Source:  STRINGDB
Pathways (18)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
4
95.9
serum gamma-glutamyl transferase measurement
3
2
2
4.3
84.7
neutrophil count
2
1
2
73
FEV/FEC ratio
1
1
1
72.9
neutrophil percentage of leukocytes
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
95.9
serum gamma-glutamyl transferase measurement
2
4.3
84.7
neutrophil count
2
73
FEV/FEC ratio
1
72.9
neutrophil percentage of leukocytes
1
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
choline/ethanolamine phosphotransferase 1
VGNC:496
457116
Macaque
choline/ethanolamine phosphotransferase 1
702700
Mouse
MGI:2139793
99712
Rat
RGD:1359727
310773
Dog
choline/ethanolamine phosphotransferase 1
VGNC:39144
612948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
choline/ethanolamine phosphotransferase 1
Macaque
choline/ethanolamine phosphotransferase 1
Mouse
Rat
Dog
choline/ethanolamine phosphotransferase 1
Publication Statistics
PubMed Score 58.73
PubMed score by year
PubTator Score 7.73
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title