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Tbio
CEP97
Centrosomal protein of 97 kDa

Protein Summary
Description
Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341893
  • ENSP00000342510
  • ENSG00000182504

Symbol
  • LRRIQ2
  • LRRIQ2
  • 2810403B08Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
small molecule perturbation
0.68
transcription factor perturbation
0.68
cell line
0.61
histone modification site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.948509738
p_ni:  0.051490262
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.944148155
p_ni:  0.055851845
Score:  0.187
Data Source:  BioPlex,STRINGDB
MRFAP1
Tbio
Novelty:  0.11341713
p_int:  0.903305567
p_ni:  0.096694433
Data Source:  BioPlex
CADPS
Tbio
Novelty:  0.01737775
p_int:  0.796035512
p_ni:  0.203964488
Data Source:  BioPlex
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.761231017
p_ni:  0.238768983
Score:  0.199
Data Source:  BioPlex,STRINGDB
CCP110
Tbio
Novelty:  0.02399511
Score:  0.997
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.988
Data Source:  STRINGDB
CEP76
Tdark
Novelty:  0.3880387
Score:  0.981
Data Source:  STRINGDB
KIF24
Tbio
Novelty:  0.13497665
Score:  0.981
Data Source:  STRINGDB
TTBK2
Tbio
Family:  Kinase
Novelty:  0.03262289
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
7.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 97
VGNC:11370
460562
Macaque
centrosomal protein 97
702482
Mouse
MGI:1921451
74201
Rat
RGD:1307400
304007
Dog
centrosomal protein 97
VGNC:53062
608540
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 97
Macaque
centrosomal protein 97
Mouse
Rat
Dog
centrosomal protein 97
Publication Statistics
PubMed Score 9.39
PubMed score by year
PubTator Score 4.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title