Tbio CEP97 Centrosomal protein of 97 kDa

Protein Summary

Description

Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.

Uniprot Accession IDs

• Q8IW35
• B5MDY8
• Q8NA71
• Q9H5T9
• Cep97

Gene Name

• CEP97

Ensembl ID

• ENST00000341893
• ENSP00000342510
• ENSG00000182504

Symbol

• LRRIQ2
• LRRIQ2
• 2810403B08Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.75
small molecule perturbation	0.68
transcription factor perturbation	0.68
cell line	0.61
histone modification site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0