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Tbio
CEP85
Centrosomal protein of 85 kDa

Protein Summary
Description
Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252992
  • ENSP00000252992
  • ENSG00000130695
  • ENST00000451429
  • ENSP00000417002
  • ENST00000640292
  • ENSP00000492362

Symbol
  • CCDC21
  • CCDC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
transcription factor perturbation
0.74
tissue sample
0.7
small molecule perturbation
0.68
tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
SOX13
Tbio
Family:  TF
Novelty:  0.02397048
p_int:  0.999958353
p_ni:  0.000009138
p_wrong:  0.000032509
Score:  0.847
Data Source:  BioPlex,STRINGDB
SOX5
Tbio
Family:  TF
Novelty:  0.00623121
p_int:  0.999730962
p_ni:  0.000269038
p_wrong:  1e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
CEP44
Tdark
Novelty:  1.20621472
p_int:  0.999436635
p_ni:  0.000540301
p_wrong:  0.000023064
Score:  0.252
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.990111559
p_ni:  0.009887992
p_wrong:  4.5e-7
Data Source:  BioPlex
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.98971202
p_ni:  0.01028798
Data Source:  BioPlex
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.959737106
p_ni:  0.040194646
p_wrong:  0.000068248
Score:  0.189
Data Source:  BioPlex,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.940987635
p_ni:  0.059012364
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
LRRC47
Tdark
Novelty:  0.73509239
Score:  0.713
Data Source:  STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
Score:  0.698
Data Source:  STRINGDB
WRAP73
Tbio
Novelty:  0.25394934
Score:  0.668
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
3
3
83.1
monocyte percentage of leukocytes
2
2
2
78
heel bone mineral density
2
1
2
68.7
eosinophil count
3
2
3
65.9
balding measurement
1
1
1
50.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
83.1
monocyte percentage of leukocytes
2
78
heel bone mineral density
2
68.7
eosinophil count
3
65.9
balding measurement
1
50.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 85
VGNC:494
456656
Macaque
centrosomal protein 85
714264
Mouse
MGI:1917262
70012
Rat
RGD:1311520
362622
Dog
centrosomal protein 85
VGNC:39140
487357
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 85
Macaque
centrosomal protein 85
Mouse
Rat
Dog
centrosomal protein 85
Publication Statistics
PubMed Score 5.95
PubMed score by year
PubTator Score 1.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title