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Tdark
CEP83
Centrosomal protein of 83 kDa

Protein Summary
Description
Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. The protein encoded by this gene is a centriolar protein involved in primary cilium assembly. Defects in this gene have been associated with infantile nephronophthisis and intellectual disability. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339839
  • ENSP00000344655
  • ENSG00000173588
  • ENST00000397809
  • ENSP00000380911

Symbol
  • CCDC41
  • CCDC41
  • NPHP18
  • NY-REN-58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
tissue sample
0.62
transcription factor binding site profile
0.62
transcription factor
0.61
cell line
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
POTEB2
Tdark
Novelty:  0.47022575
p_int:  0.999999988
p_ni:  1.2e-8
Data Source:  BioPlex
POTEC
Tdark
Novelty:  1.98957109
p_int:  0.999999841
p_ni:  1.59e-7
Score:  0.672
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.999997868
p_ni:  0.000002132
Data Source:  BioPlex
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999976737
p_ni:  2.6e-7
p_wrong:  0.000023003
Score:  0.175
Data Source:  BioPlex,STRINGDB
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.96687494
p_ni:  0.03312506
Score:  0.51
Data Source:  BioPlex,STRINGDB
CKAP5
Tbio
Novelty:  0.00623771
p_int:  0.935275161
p_ni:  0.064724839
Score:  0.917
Data Source:  BioPlex,STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
Score:  0.993
Data Source:  STRINGDB
CEP89
Tbio
Novelty:  0.17461805
Score:  0.991
Data Source:  STRINGDB
FBF1
Tbio
Novelty:  0.0409747
Score:  0.981
Data Source:  STRINGDB
CEP164
Tbio
Novelty:  0.04775724
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
1
1
0
1.1
59.8
multiple sclerosis
1
1
0
1.1
35.5
vital capacity
1
1
0
21.2
34.5
chloride measurement
1
1
1
23.7
sodium measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
0
1.1
59.8
multiple sclerosis
0
1.1
35.5
vital capacity
0
21.2
34.5
chloride measurement
1
23.7
sodium measurement
1
21.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 83
VGNC:5335
452131
Macaque
centrosomal protein 83
711408
Mouse
MGI:1924298
77048
Rat
RGD:1359593
366872
Dog
centrosomal protein 83
VGNC:39139
482606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 83
Macaque
centrosomal protein 83
Mouse
Rat
Dog
centrosomal protein 83
Publication Statistics
PubMed Score 8.28
PubMed score by year
PubTator Score 2.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title