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Tdark
CEP76
Centrosomal protein of 76 kDa

Protein Summary
Description
Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262127
  • ENSP00000262127
  • ENSG00000101624
  • ENST00000423709
  • ENSP00000403074

Symbol
  • C18orf9
  • C18orf9
  • HsT1705
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.94
tissue sample
0.71
kinase perturbation
0.66
cell line
0.63
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
CCDC74A
Tdark
Novelty:  1.52601156
p_int:  0.999992868
p_ni:  0.000007132
Data Source:  BioPlex
RPS6KB2
Tchem
Family:  Kinase
Novelty:  0.02143353
p_int:  0.999979938
p_ni:  0.000020062
Data Source:  BioPlex
FHL5
Tbio
Novelty:  0.27618006
p_int:  0.999963572
p_ni:  0.000036365
p_wrong:  6.3e-8
Score:  0.21
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999388394
p_ni:  0.000611606
Data Source:  BioPlex
RPL9
Tbio
Novelty:  0.00845583
p_int:  0.967489238
p_ni:  0.032510762
Score:  0.282
Data Source:  BioPlex,STRINGDB
WIPI1
Tbio
Novelty:  0.01070744
p_int:  0.961767747
p_ni:  0.038232248
p_wrong:  5e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
KCTD10
Tbio
Novelty:  0.10573929
p_int:  0.876547102
p_ni:  0.123452898
Score:  0.163
Data Source:  BioPlex,STRINGDB
RSPO1
Tbio
Novelty:  0.00365075
p_int:  0.765755989
p_ni:  0.233593253
p_wrong:  0.000650758
Score:  0.226
Data Source:  BioPlex,STRINGDB
CCP110
Tbio
Novelty:  0.02399511
Score:  0.991
Data Source:  STRINGDB
CEP97
Tbio
Novelty:  0.12709162
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
77.9
juvenile idiopathic arthritis
1
1
0
1.3
61
red blood cell density measurement
1
1
1
49.5
pulse pressure measurement
1
1
1
47.7
1
1
0
1.3
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
77.9
juvenile idiopathic arthritis
0
1.3
61
red blood cell density measurement
1
49.5
pulse pressure measurement
1
47.7
0
1.3
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 76
VGNC:5150
455506
Mouse
MGI:1923401
225659
Rat
RGD:1305183
291540
Dog
centrosomal protein 76
VGNC:39137
480214
Horse
centrosomal protein 76
VGNC:16427
100050324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 76
Mouse
Rat
Dog
centrosomal protein 76
Horse
centrosomal protein 76
Publication Statistics
PubMed Score 2.45
PubMed score by year
PubTator Score 1.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title