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Tbio
CEP72
Centrosomal protein of 72 kDa

Protein Summary
Description
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264935
  • ENSP00000264935
  • ENSG00000112877

Symbol
  • KIAA1519
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
virus perturbation
0.85
cell line
0.69
ligand (protein) perturbation
0.59
cellular component
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.999999997
p_ni:  3e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.999997836
p_ni:  0.000002162
p_wrong:  2e-9
Data Source:  BioPlex
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.999996925
p_ni:  0.000002157
p_wrong:  9.18e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
SPATA24
Tdark
Novelty:  0.95478351
p_int:  0.999993177
p_ni:  2.47e-7
p_wrong:  0.000006576
Score:  0.193
Data Source:  BioPlex,STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999034396
p_ni:  0.000965604
Data Source:  BioPlex
ZKSCAN1
Tbio
Family:  TF
Novelty:  0.08190662
p_int:  0.990180459
p_ni:  0.009819383
p_wrong:  1.57e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.911224634
p_ni:  0.088775366
Data Source:  BioPlex
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.878924128
p_ni:  0.121075872
Score:  0.309
Data Source:  BioPlex,STRINGDB
CTU2
Tdark
Novelty:  0.00936441
p_int:  0.814042627
p_ni:  0.185957373
Score:  0.214
Data Source:  BioPlex,STRINGDB
CHAF1B
Tbio
Novelty:  0.05899435
p_int:  0.803850378
p_ni:  0.196149622
Score:  0.262
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
59
lung disease associated with cystic fibrosis
1
2
2
52.7
2
2
0
1.3
45.6
2
2
1
1.2
36.9
3
2
0
1.1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
59
lung disease associated with cystic fibrosis
2
52.7
0
1.3
45.6
1
1.2
36.9
0
1.1
36.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 72
VGNC:3948
461689
Macaque
centrosomal protein 72
708753
Mouse
MGI:1921720
74470
Rat
RGD:1566336
308064
Dog
centrosomal protein 72
VGNC:39136
478632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 72
Macaque
centrosomal protein 72
Mouse
Rat
Dog
centrosomal protein 72
Publication Statistics
PubMed Score 16.48
PubMed score by year
PubTator Score 7.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title