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Tbio
CEP55
Centrosomal protein of 55 kDa

Protein Summary
Description
Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371485
  • ENSP00000360540
  • ENSG00000138180

Symbol
  • C10orf3
  • URCC6
  • CT111
  • MARCH
  • URCC6
  • C10orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
drug perturbation
0.87
histone modification site profile
0.83
interacting protein
0.77
transcription factor binding site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.69   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.69   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (244)
BSPRY
Tdark
Novelty:  0.38200913
p_int:  0.999999852
p_ni:  1.48e-7
Data Source:  BioPlex
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.999999407
p_ni:  5.93e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
p_int:  0.999999201
p_ni:  7.99e-7
Data Source:  BioPlex
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999997913
p_ni:  0.000002087
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999900472
p_ni:  0.000099527
p_wrong:  2e-9
Data Source:  BioPlex
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999899023
p_ni:  0.00010091
p_wrong:  6.6e-8
Data Source:  BioPlex
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.999319858
p_ni:  0.000680142
Data Source:  BioPlex
ENTHD1
Tdark
Novelty:  5.29427978
p_int:  0.998887413
p_ni:  0.001112241
p_wrong:  3.46e-7
Data Source:  BioPlex
CALCOCO2
Tbio
Novelty:  0.01456844
p_int:  0.996510408
p_ni:  0.003489571
p_wrong:  2.1e-8
Score:  0.55
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.987441355
p_ni:  0.011278534
p_wrong:  0.001280111
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
82.8
waist-hip ratio
3
5
6
80.9
vitamin A measurement
1
1
1
62.8
waist circumference
1
1
1
56.4
BMI-adjusted waist circumference
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
82.8
waist-hip ratio
6
80.9
vitamin A measurement
1
62.8
waist circumference
1
56.4
BMI-adjusted waist circumference
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 55
VGNC:1604
466162
Macaque
centrosomal protein 55
699890
Mouse
MGI:1921357
74107
Rat
RGD:1305340
294074
Dog
centrosomal protein 55
VGNC:39130
477773
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 55
Macaque
centrosomal protein 55
Mouse
Rat
Dog
centrosomal protein 55
Publication Statistics
PubMed Score 97.69
PubMed score by year
PubTator Score 31.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title