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Tbio
CEP295
Centrosomal protein of 295 kDa

Protein Summary
Description
Centriole-enriched microtubule-binding protein involved in centriole biogenesis (PubMed:20844083, PubMed:25131205, PubMed:27185865). Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure (PubMed:27185865). Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles (PubMed:27185865). Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement (PubMed:25131205). Binds to and stabilizes centriolar microtubule (PubMed:27185865).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325212
  • ENSP00000316681
  • ENSG00000166004
  • ENST00000531700
  • ENSP00000437323

Symbol
  • KIAA1731
  • KIAA1731
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor binding site profile
0.66
tissue
0.65
cell line
0.62
small molecule perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999990286
p_ni:  0.000009706
p_wrong:  8e-9
Data Source:  BioPlex
SPICE1
Tbio
Novelty:  0.19045168
p_int:  0.999982413
p_ni:  0.000017578
p_wrong:  9e-9
Score:  0.542
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999711788
p_ni:  0.000100095
p_wrong:  0.000188117
Score:  0.183
Data Source:  BioPlex,STRINGDB
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.999244618
p_ni:  0.000010052
p_wrong:  0.00074533
Score:  0.537
Data Source:  BioPlex,STRINGDB
CEP152
Tbio
Novelty:  0.02129779
Score:  0.909
Data Source:  STRINGDB
CEP135
Tbio
Novelty:  0.03507768
Score:  0.898
Data Source:  STRINGDB
SASS6
Tbio
Novelty:  0.00680548
Score:  0.792
Data Source:  STRINGDB
CEP120
Tbio
Novelty:  0.07215656
Score:  0.777
Data Source:  STRINGDB
CEP97
Tbio
Novelty:  0.12709162
Score:  0.721
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.711
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Intraflagellar transport proteins binding to dynein
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Genes related to primary cilium development (based on CRISPR)
Genes related to primary cilium development (based on CRISPR)
Genes related to primary cilium development (based on CRISPR)
Intraflagellar transport proteins binding to dynein
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
2
71.9
smoking status measurement
1
1
1
26.6
mathematical ability
3
1
3
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
71.9
smoking status measurement
1
26.6
mathematical ability
3
4.3
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 295
VGNC:3154
451482
Macaque
centrosomal protein 295
697392
Mouse
MGI:2442521
319675
Rat
RGD:1311723
363018
Dog
centrosomal protein 295
VGNC:39126
100683524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 295
Macaque
centrosomal protein 295
Mouse
Rat
Dog
centrosomal protein 295
Publication Statistics
PubMed Score 5.84
PubMed score by year
PubTator Score 2.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title