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Tbio
CEP290
Centrosomal protein of 290 kDa

Protein Summary
Description
Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000547691
  • ENSP00000446905
  • ENSG00000198707
  • ENST00000552810
  • ENSP00000448012

Symbol
  • BBS14
  • KIAA0373
  • NPHP6
  • CT87
  • MKS4
  • POC3
  • rd16
  • BBS14
  • JBTS5
  • LCA10
  • NPHP6
  • SLSN6
  • 3H11Ag
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
phenotype
0.79
biological process
0.75
tissue
0.72
cellular component
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.05   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.05   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (321)
IQCB1
Tbio
Novelty:  0.02979098
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999838389
p_ni:  0.000161611
Data Source:  BioPlex
MCM7
Tbio
Novelty:  0.0017984
p_int:  0.983957379
p_ni:  0.002968513
p_wrong:  0.013074108
Score:  0.198
Data Source:  BioPlex,STRINGDB
PEG10
Tbio
Novelty:  0.00478545
p_int:  0.980118237
p_ni:  0.011076475
p_wrong:  0.008805288
Score:  0.806
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.977663976
p_ni:  0.007290137
p_wrong:  0.015045887
Data Source:  BioPlex
CCP110
Tbio
Novelty:  0.02399511
Score:  0.997
Data Source:  STRINGDB
RPGRIP1L
Tbio
Novelty:  0.00819421
Score:  0.994
Data Source:  STRINGDB
AHI1
Tbio
Novelty:  0.01180688
Score:  0.992
Data Source:  STRINGDB
CC2D2A
Tbio
Novelty:  0.03684487
Score:  0.992
Data Source:  STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 290
VGNC:5334
452113
Macaque
centrosomal protein 290
708286
Mouse
MGI:2384917
216274
Rat
RGD:1311640
314787
Dog
centrosomal protein 290
VGNC:39125
482591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 290
Macaque
centrosomal protein 290
Mouse
Rat
Dog
centrosomal protein 290
Publication Statistics
PubMed Score 217.05
PubMed score by year
PubTator Score 100.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title