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Tbio
CEP170
Centrosomal protein of 170 kDa

Protein Summary
Description
Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366542
  • ENSP00000355500
  • ENSG00000143702
  • ENST00000366543
  • ENSP00000355501
  • ENST00000366544
  • ENSP00000355502
  • ENST00000450306
  • ENSP00000482707
  • ENSG00000276725
  • ENST00000612450
  • ENSP00000483344
  • ENST00000621831
  • ENSP00000484359

Symbol
  • FAM68A
  • KAB
  • KIAA0470
  • KAB
  • FAM68A
  • KIAA0470
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
protein complex
0.97
cellular component
0.78
transcription factor binding site profile
0.72
cell line
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.9   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.9   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
CEP170P1
Tdark
p_int:  1
Data Source:  BioPlex
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.999999995
p_ni:  5e-9
Data Source:  BioPlex
DAPK3
Tchem
Family:  Kinase
Novelty:  0.01551494
p_int:  0.999999916
p_ni:  8.4e-8
Score:  0.307
Data Source:  BioPlex,STRINGDB
NIN
Tbio
Novelty:  0.01312714
p_int:  0.999999783
p_ni:  2.11e-7
p_wrong:  6e-9
Score:  0.974
Data Source:  BioPlex,STRINGDB
SYNE2
Tbio
Novelty:  0.01368736
p_int:  0.999999282
p_ni:  7.12e-7
p_wrong:  7e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999999157
p_ni:  8.4e-7
p_wrong:  4e-9
Data Source:  BioPlex
PCYT1A
Tchem
Family:  Enzyme
Novelty:  0.00621528
p_int:  0.999998741
p_ni:  0.000001259
Score:  0.181
Data Source:  BioPlex,STRINGDB
RUFY2
Tbio
Novelty:  0.50188929
p_int:  0.999997858
p_ni:  0.000002141
p_wrong:  2e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
RFWD3
Tbio
Family:  Enzyme
Novelty:  0.0859205
p_int:  0.9999972
p_ni:  0.0000028
Data Source:  BioPlex
CEP170B
Tdark
Novelty:  0.30498676
p_int:  0.999996279
p_ni:  0.000002286
p_wrong:  0.000001435
Score:  0.57
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
5
4
5.9
94
self reported educational attainment
5
5
4
5.9
94
mathematical ability
4
4
4
90.2
mathematical ability
4
4
4
90.2
glomerular filtration rate
5
3
5
6.7
89.9
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
5.9
94
self reported educational attainment
4
5.9
94
mathematical ability
4
90.2
mathematical ability
4
90.2
glomerular filtration rate
5
6.7
89.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 170
VGNC:10565
457860
Macaque
centrosomal protein 170
705427
Mouse
MGI:1918348
545389
Dog
centrosomal protein 170
VGNC:39122
480096
Horse
centrosomal protein 170
VGNC:16412
100054866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 170
Macaque
centrosomal protein 170
Mouse
Dog
centrosomal protein 170
Horse
centrosomal protein 170
Publication Statistics
PubMed Score 16.90
PubMed score by year
PubTator Score 8.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title