Tbio CEP162 Centrosomal protein of 162 kDa

Protein Summary

Description

Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.

Uniprot Accession IDs

• Q5TB80
• A6PVL7
• A6PVL8
• Q6P475
• Q9Y2L2
• Cep162

Gene Name

• CEP162

Ensembl ID

• ENST00000257766
• ENSP00000257766
• ENSG00000135315
• ENST00000403245
• ENSP00000385215
• ENST00000617909
• ENSP00000481760

Symbol

• C6orf84
• KIAA1009
• QN1
• QN1
• C6orf84
• KIAA1009

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
histone modification site profile	0.91
transcription factor binding site profile	0.67
cell line	0.62
cellular component	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.75   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 31   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.75   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0