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Tbio
CEP135
Centrosomal protein of 135 kDa

Protein Summary
Description
Involved in early centriole assembly/duplication/biogenesis/formation/. Required for centriole elongation. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257287
  • ENSP00000257287
  • ENSG00000174799
  • ENST00000422247
  • ENSP00000412799

Symbol
  • CEP4
  • KIAA0635
  • CEP4
  • MCPH8
  • KIAA0635
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
histone modification site profile
0.8
microRNA
0.63
cellular component
0.61
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.96   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.96   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (199)
TXLNB
Tbio
Novelty:  0.12751933
p_int:  0.99999997
p_ni:  1.6e-8
p_wrong:  1.4e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
WRAP73
Tbio
Novelty:  0.25394934
p_int:  0.999999837
p_ni:  1.63e-7
Score:  0.894
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999999588
p_ni:  4.11e-7
Score:  0.37
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999998285
p_ni:  0.000001714
Score:  0.288
Data Source:  BioPlex,STRINGDB
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999998011
p_ni:  0.000001989
Data Source:  BioPlex
CARD9
Tbio
Family:  Enzyme
Novelty:  0.00547101
p_int:  0.999942036
p_ni:  0.000057948
p_wrong:  1.6e-8
Score:  0.534
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.999548924
p_ni:  0.000431618
p_wrong:  0.000019459
Data Source:  BioPlex
PLK4
Tchem
Family:  Kinase
Novelty:  0.00265851
Score:  0.996
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.996
Data Source:  STRINGDB
CEP152
Tbio
Novelty:  0.02129779
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 135
VGNC:2953
461311
Macaque
centrosomal protein 135
696309
Mouse
MGI:2681869
381644
Rat
RGD:1310726
305288
Dog
centrosomal protein 135
VGNC:39118
482157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 135
Macaque
centrosomal protein 135
Mouse
Rat
Dog
centrosomal protein 135
Publication Statistics
PubMed Score 28.96
PubMed score by year
PubTator Score 16.73
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title