You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CEP131
Centrosomal protein of 131 kDa

Protein Summary
Description
Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269392
  • ENSP00000269392
  • ENSG00000141577
  • ENST00000374782
  • ENSP00000363914
  • ENST00000450824
  • ENSP00000393583

Symbol
  • AZI1
  • KIAA1118
  • AZ1
  • ZA1
  • AZI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
ligand (protein) perturbation
0.83
cellular component
0.77
gene perturbation
0.7
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999999697
p_ni:  2.16e-7
p_wrong:  8.7e-8
Score:  0.172
Data Source:  BioPlex,STRINGDB
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999998329
p_ni:  0.000001669
p_wrong:  2e-9
Data Source:  BioPlex
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999993887
p_ni:  0.000006112
p_wrong:  1e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
TSSK1B
Tchem
Family:  Kinase
Novelty:  0.01931035
p_int:  0.999983718
p_ni:  0.000016281
p_wrong:  1e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.999982831
p_ni:  0.000017168
Data Source:  BioPlex
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.999973196
p_ni:  0.000026804
Score:  0.183
Data Source:  BioPlex,STRINGDB
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.996595516
p_ni:  0.003313639
p_wrong:  0.000090845
Data Source:  BioPlex
TEX264
Tbio
Novelty:  0.32406417
p_int:  0.993672934
p_ni:  0.006202311
p_wrong:  0.000124754
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.993502502
p_ni:  0.006491259
p_wrong:  0.00000624
Score:  0.193
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.993069622
p_ni:  0.00688085
p_wrong:  0.000049527
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
5
5
3
6.7
85.6
appendicular lean mass
3
1
3
79.4
body mass index
2
2
2
77
daytime rest measurement
1
1
1
68.3
depressive symptom measurement
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
6.7
85.6
appendicular lean mass
3
79.4
body mass index
2
77
daytime rest measurement
1
68.3
depressive symptom measurement
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 131
VGNC:9231
454954
Macaque
centrosomal protein 131
718613
Mouse
MGI:107440
12009
Rat
RGD:1307745
360672
Dog
centrosomal protein 131
VGNC:51939
483359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 131
Macaque
centrosomal protein 131
Mouse
Rat
Dog
centrosomal protein 131
Publication Statistics
PubMed Score 43.25
PubMed score by year
PubTator Score 32.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title