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Tbio
CENPX
Centromere protein X

Protein Summary
Description
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-lik ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306704
  • ENSP00000302951
  • ENSG00000169689
  • ENST00000392359
  • ENSP00000376168
  • ENST00000580435
  • ENSP00000462015

Symbol
  • FAAP10
  • MHF2
  • STRA13
  • D9
  • MHF2
  • CENP-X
  • FAAP10
  • STRA13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.44   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.44   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
FANCC
Tbio
Novelty:  0.00546581
Score:  0.999
Data Source:  STRINGDB
FANCL
Tbio
Family:  Enzyme
Novelty:  0.00274467
Score:  0.999
Data Source:  STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
Score:  0.999
Data Source:  STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.999
Data Source:  STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.999
Data Source:  STRINGDB
FANCF
Tchem
Novelty:  0.01745498
Score:  0.999
Data Source:  STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.999
Data Source:  Reactome,STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.999
Data Source:  Reactome,STRINGDB
FAAP24
Tbio
Novelty:  0.08081633
Score:  0.999
Data Source:  Reactome,STRINGDB
FANCE
Tbio
Novelty:  0.04484113
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
76.5
vital capacity
1
1
1
73.2
BMI-adjusted waist-hip ratio
2
3
3
58.3
birth weight
2
2
2
55.2
forced expiratory volume
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
76.5
vital capacity
1
73.2
BMI-adjusted waist-hip ratio
3
58.3
birth weight
2
55.2
forced expiratory volume
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein X
VGNC:48942
454980
Macaque
centromere protein X
719290
Mouse
MGI:894324
20892
Cow
centromere protein X
VGNC:27188
618018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein X
Macaque
centromere protein X
Mouse
Cow
centromere protein X
Publication Statistics
PubMed Score 10.44
PubMed score by year
PubTator Score 27.24
PubTator score by year
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Related Publications
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PMID
Year
Title