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Tbio
CENPV
Centromere protein V

Protein Summary
Description
Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299736
  • ENSP00000299736
  • ENSG00000166582

Symbol
  • PRR6
  • p30
  • PRR6
  • CENP-V
  • 3110013H01Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor perturbation
0.94
disease perturbation
0.74
histone modification site profile
0.72
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.999333809
p_ni:  0.000666179
p_wrong:  1.2e-8
Score:  0.245
Data Source:  BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.997331232
p_ni:  0.001353171
p_wrong:  0.001315597
Data Source:  BioPlex
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.997009917
p_ni:  0.002990045
p_wrong:  3.7e-8
Data Source:  BioPlex
LGALS13
Tbio
Novelty:  0.00695816
p_int:  0.996482462
p_ni:  0.003517518
p_wrong:  1.9e-8
Score:  0.265
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.99574327
p_ni:  0.003104839
p_wrong:  0.001151891
Data Source:  BioPlex
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
p_int:  0.983046103
p_ni:  0.002000517
p_wrong:  0.014953379
Score:  0.26
Data Source:  BioPlex,STRINGDB
ILF2
Tbio
Novelty:  0.01598188
p_int:  0.945742169
p_ni:  0.050622316
p_wrong:  0.003635515
Score:  0.244
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.922579305
p_ni:  0.075313922
p_wrong:  0.002106772
Data Source:  BioPlex
HBZ
Tbio
Novelty:  0.00331625
Score:  0.76
Data Source:  STRINGDB
EMB
Tbio
Novelty:  0.00135577
Score:  0.738
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
4
4
89.9
neutrophil percentage of leukocytes
2
2
2
85.7
lymphocyte percentage of leukocytes
2
2
2
85.7
leukocyte count
3
2
3
81.3
monocyte percentage of leukocytes
2
2
2
74.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
89.9
neutrophil percentage of leukocytes
2
85.7
lymphocyte percentage of leukocytes
2
85.7
leukocyte count
3
81.3
monocyte percentage of leukocytes
2
74.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein V
VGNC:51642
455013
Mouse
MGI:1920389
73139
Rat
RGD:1565681
501702
Dog
centromere protein V
VGNC:53316
489523
Opossum
centromere protein V
100617555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein V
Mouse
Rat
Dog
centromere protein V
Opossum
centromere protein V
Publication Statistics
PubMed Score 635.53
PubMed score by year
PubTator Score 446.51
PubTator score by year
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Related Publications
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PMID
Year
Title