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Tbio
CENPT
Centromere protein T

Protein Summary
Description
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440851
  • ENSP00000400140
  • ENSG00000102901
  • ENST00000562787
  • ENSP00000457810

Symbol
  • C16orf56
  • ICEN22
  • CENP-T
  • C16orf56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.8
transcription factor binding site profile
0.77
tissue sample
0.67
tissue
0.62
small molecule perturbation
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.03   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.03   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
CENPW
Tbio
Novelty:  0.04397484
p_int:  0.999991755
p_ni:  0.000008244
Score:  0.999
Data Source:  BioPlex,STRINGDB
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999984769
p_ni:  0.000015161
p_wrong:  7e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.998
Data Source:  STRINGDB
CENPO
Tbio
Novelty:  0.12059767
Score:  0.996
Data Source:  STRINGDB
CENPH
Tbio
Novelty:  0.02845079
Score:  0.994
Data Source:  STRINGDB
ITGB3BP
Tbio
Novelty:  0.06162186
Score:  0.992
Data Source:  STRINGDB
SPC25
Tbio
Novelty:  0.26354244
Score:  0.991
Data Source:  STRINGDB
CENPU
Tbio
Novelty:  0.03681625
Score:  0.99
Data Source:  STRINGDB
CENPA
Tbio
Novelty:  0.00154245
Score:  0.99
Data Source:  STRINGDB
CENPN
Tbio
Novelty:  0.06923443
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
14
14
23
10
99.4
apolipoprotein A 1 measurement
2
5
5
98.4
hemoglobin measurement
3
3
3
92.7
stem Cell Factor measurement
1
2
2
92.4
hematocrit
3
3
3
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
23
10
99.4
apolipoprotein A 1 measurement
5
98.4
hemoglobin measurement
3
92.7
stem Cell Factor measurement
2
92.4
hematocrit
3
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443939
320394
Rat
RGD:1309383
307805
Horse
centromere protein T
VGNC:16403
100053509
Cow
centromere protein T
VGNC:27185
513195
Chicken
centromere protein T
CGNC:1063
415654
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
centromere protein T
Cow
centromere protein T
Chicken
centromere protein T
Publication Statistics
PubMed Score 31.03
PubMed score by year
PubTator Score 16.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title