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Tbio
CENPJ
Centromere protein J

Protein Summary
Description
Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). This gene encodes a protein that belongs to the centromere protein family. During cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381884
  • ENSP00000371308
  • ENSG00000151849
  • ENST00000616936
  • ENSP00000477511

Symbol
  • CPAP
  • LAP
  • LIP1
  • LAP
  • CPAP
  • LIP1
  • BM032
  • MCPH6
  • SASS4
  • SCKL4
  • Sas-4
  • CENP-J
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
cellular component
0.7
interacting protein
0.63
transcription factor perturbation
0.61
transcription factor binding site profile
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.53   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.53   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0