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Tbio
CENPH
Centromere protein H

Protein Summary
Description
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283006
  • ENSP00000283006
  • ENSG00000153044

Symbol
  • ICEN35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.68
cellular component
0.66
transcription factor binding site profile
0.59
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.17   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.17   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (223)
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.999999566
p_ni:  4.34e-7
Data Source:  BioPlex
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.999998692
p_ni:  0.000001308
Score:  0.179
Data Source:  BioPlex,STRINGDB
TEKT2
Tbio
Novelty:  0.04607893
p_int:  0.99996101
p_ni:  0.00003899
Score:  0.181
Data Source:  BioPlex,STRINGDB
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.99930398
p_ni:  0.00069602
Data Source:  BioPlex
CCDC151
Tbio
Novelty:  0.15952702
p_int:  0.994504561
p_ni:  0.005495397
p_wrong:  4.2e-8
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.994231101
p_ni:  0.005768898
p_wrong:  1e-9
Score:  0.245
Data Source:  BioPlex,STRINGDB
CENPU
Tbio
Novelty:  0.03681625
p_int:  0.983564281
p_ni:  0.016435719
Score:  0.996
Data Source:  BioPlex,STRINGDB
LMAN2
Tbio
Novelty:  0.02922729
p_int:  0.983559128
p_ni:  0.016440872
Score:  0.234
Data Source:  BioPlex,STRINGDB
CCDC107
Tdark
Novelty:  1.10682722
p_int:  0.974117646
p_ni:  0.025882354
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.971845915
p_ni:  0.028154085
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
90.4
leukocyte count
2
2
2
86.1
neutrophil percentage of leukocytes
2
2
2
83.7
sum of basophil and neutrophil counts
1
1
1
64.9
granulocyte count
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
90.4
leukocyte count
2
86.1
neutrophil percentage of leukocytes
2
83.7
sum of basophil and neutrophil counts
1
64.9
granulocyte count
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein H
VGNC:3945
742423
Macaque
centromere protein H
699620
Mouse
MGI:1349448
26886
Rat
RGD:1583506
681185
Dog
centromere protein H
VGNC:39104
610124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein H
Macaque
centromere protein H
Mouse
Rat
Dog
centromere protein H
Publication Statistics
PubMed Score 38.17
PubMed score by year
PubTator Score 27.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title