Tbio CENPA Histone H3-like centromeric protein A

Protein Summary

Description

Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P49450
• D6W544
• Q53T74
• Q9BVW2

Gene Name

• CENPA

Ensembl ID

• ENST00000233505
• ENSP00000233505
• ENSG00000115163
• ENST00000335756
• ENSP00000336868

Symbol

• CenH3
• CENP-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor perturbation	0.91
histone modification site profile	0.85
transcription factor binding site profile	0.83
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.77   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 492   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.77   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (383)

Explore Interacting Targets

1 – 10 of 383

• See Interactions on String-DB

HJURP

Tbio

Novelty:  0.02317704

p_int:  0.999939761

p_ni:  0.000060239

Score:  0.999

Data Source:  BioPlex,STRINGDB

SUPT16H

Tbio

Family:  Enzyme

Novelty:  0.01026868

p_int:  0.988786627

p_ni:  0.011213373

Score:  0.732

Data Source:  BioPlex,STRINGDB

OIP5

Tbio

Novelty:  0.02546471

p_int:  0.960824529

p_ni:  0.001275148

p_wrong:  0.037900323

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

ARL10

Tdark

Family:  Enzyme

Novelty:  1.16329406

p_int:  0.915470298

p_ni:  0.084529702

Score:  0.164

Data Source:  BioPlex,STRINGDB

MIS18A

Tbio

Novelty:  0.08143008

p_int:  0.884090745

p_ni:  0.003474133

p_wrong:  0.112435122

Score:  0.966

Data Source:  BioPlex,Reactome,STRINGDB

SSRP1

Tbio

Family:  TF

Novelty:  0.0143993

p_int:  0.848212092

p_ni:  0.151787908

Score:  0.774

Data Source:  BioPlex,STRINGDB

H2AFY

Tbio

Novelty:  0.01150729

p_int:  0.831402262

p_ni:  0.168597738

Score:  0.857

Data Source:  BioPlex,STRINGDB

MCM4

Tchem

Novelty:  0.00604311

p_int:  0.798665861

p_ni:  0.201334139

Score:  0.882

Data Source:  BioPlex,STRINGDB

CENPN

Tbio

Novelty:  0.06923443

Score:  0.999

Data Source:  STRINGDB

AURKA

Tchem

Family:  Kinase

Novelty:  0.0010868

Score:  0.998

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (22)

Reactome (19)

PathwayCommons (3)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (3)

Components (10)

Processes (7)

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1 – 3 of 3

GO Term	Evidence	Assigned by
nucleosomal DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chromatin binding	Traceable Author Statement (TAS)	ProtInc
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (27)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	5	5	8		89.9
triglyceride measurement	EFO_0004530	2	3	3		89.4
hypertension	EFO_0000537	2	5	5		88.6
C-reactive protein measurement	EFO_0004458	2	3	4		84
Calcium channel blocker use measurement	EFO_0009930	1	1	1		80

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
diastolic blood pressure	EFO_0006336	8		89.9
triglyceride measurement	EFO_0004530	3		89.4
hypertension	EFO_0000537	5		88.6
C-reactive protein measurement	EFO_0004458	4		84
Calcium channel blocker use measurement	EFO_0009930	1		80

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ADP-ribosylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Complete proteome
DNA-binding
Host-virus interaction

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
Agents acting on the renin-angiotensin system use measurement
Antihypertensive use measurement
apolipoprotein B measurement
Beta blocking agent use measurement
BMI-adjusted waist-hip ratio
body height
body mass index
C-reactive protein measurement
Calcium channel blocker use measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	centromere protein A	VGNC:191	459086
Macaque	centromere protein A		697312
Mouse	centromere protein A	MGI:88375	12615
Rat	centromere protein A	RGD:1563607	298850
Dog	centromere protein A	VGNC:39101	475692

Species	Name	OMA	EggNOG	Inparanoid
Chimp	centromere protein A
Macaque	centromere protein A
Mouse	centromere protein A
Rat	centromere protein A
Dog	centromere protein A

Publication Statistics

PubMed Score 698.77

PubMed score by year

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PubTator Score 386.11

PubTator score by year

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Related Publications

Text Mined References (123)

GeneRif Annotations (91)

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PMID	Year	Title