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Tbio
CEMIP2
Cell surface hyaluronidase

Protein Summary
Description
Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172). This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377044
  • ENSP00000366243
  • ENSG00000135048
  • ENST00000377066
  • ENSP00000366266

Symbol
  • KIAA1412
  • TMEM2
  • TMEM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.88
small molecule perturbation
0.84
microRNA
0.79
PubMedID
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
CRP
Tbio
Novelty:  0.00001517
p_int:  0.999991947
p_ni:  0.000008053
Data Source:  BioPlex
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.999424181
p_ni:  0.000575817
p_wrong:  2e-9
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.999028522
p_ni:  0.000971472
p_wrong:  6e-9
Data Source:  BioPlex
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.99813967
p_ni:  0.001860316
p_wrong:  1.5e-8
Data Source:  BioPlex
CST9L
Tdark
Novelty:  0.21941207
p_int:  0.997862834
p_ni:  0.002137147
p_wrong:  1.8e-8
Data Source:  BioPlex
EDDM3A
Tdark
Novelty:  0.05607223
p_int:  0.995375794
p_ni:  0.004623611
p_wrong:  5.95e-7
Data Source:  BioPlex
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.992755934
p_ni:  0.007244059
p_wrong:  7e-9
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.992682878
p_ni:  0.007317061
p_wrong:  6e-8
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.98959305
p_ni:  0.01040695
Data Source:  BioPlex
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.987120486
p_ni:  0.012871676
p_wrong:  0.000007838
Score:  0.527
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risky sexual behaviour measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risky sexual behaviour measurement
1
14.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell migration inducing hyaluronidase 2
VGNC:4879
464523
Macaque
transmembrane protein 2
703378
Mouse
MGI:1890373
83921
Rat
RGD:1307941
309400
Dog
cell migration inducing hyaluronidase 2
VGNC:47518
484171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell migration inducing hyaluronidase 2
Macaque
transmembrane protein 2
Mouse
Rat
Dog
cell migration inducing hyaluronidase 2
Publication Statistics
PubMed Score 21.61
PubMed score by year
PubTator Score 8.61
PubTator score by year
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Related Publications
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PMID
Year
Title