Tbio CELSR1 Cadherin EGF LAG seven-pass G-type receptor 1

Protein Summary

Description

Receptor that may have an important role in cell/cell signaling during nervous system formation. The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYQ6
• O95722
• Q5TH47
• Q9BWQ5
• Q9Y506
• Q9Y526

Gene Name

• CELSR1

Ensembl ID

• ENST00000262738
• ENSP00000262738
• ENSG00000075275

Symbol

• CDHF9
• FMI2
• ME2
• FMI2
• CDHF9
• HFMI2
• ADGRC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.83
phenotype	0.8
biological process	0.67
disease	0.64

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Cadherin Egf Lag Seven-pass G-type Receptor 1

Protein / Cell Adhesion Molecule / Cadherin / Cadherin Egf Lag Seven-pass G-type Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Cadherin Egf Lag (Celsr) Receptor / Cadherin Egf Lag Seven-pass G-type Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.49   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.49   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0