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Tbio
CELF3
CUGBP Elav-like family member 3

Protein Summary
Description
RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290583
  • ENSP00000290583
  • ENSG00000159409
  • ENST00000290585
  • ENSP00000290585

Symbol
  • BRUNOL1
  • CAGH4
  • ERDA4
  • TNRC4
  • CAGH4
  • ERDA4
  • ETR-1
  • TNRC4
  • BRUNOL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.86
gene perturbation
0.78
transcription factor
0.6
cell type or tissue
0.57
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
CELF5
Tbio
Novelty:  0.04733002
p_int:  0.999919723
p_ni:  1.1e-8
p_wrong:  0.000080266
Score:  0.481
Data Source:  BioPlex,STRINGDB
MKRN1
Tbio
Family:  Enzyme
Novelty:  0.04485183
p_int:  0.979268814
p_ni:  0.020381264
p_wrong:  0.000349923
Score:  0.269
Data Source:  BioPlex,STRINGDB
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
Score:  0.757
Data Source:  STRINGDB
CEBPD
Tbio
Family:  TF
Novelty:  0.00121121
Score:  0.733
Data Source:  STRINGDB
SRRM4
Tbio
Novelty:  0.05759645
Score:  0.73
Data Source:  STRINGDB
TNNT2
Tbio
Novelty:  0.00044568
Score:  0.714
Data Source:  STRINGDB
MBNL2
Tbio
Novelty:  0.02398556
Score:  0.652
Data Source:  STRINGDB
RRM1
Tclin
Family:  Enzyme
Novelty:  0.00083196
Score:  0.625
Data Source:  STRINGDB
SCRT1
Tbio
Family:  TF
Novelty:  0.0324512
Score:  0.621
Data Source:  STRINGDB
GRIN1
Tclin
Family:  IC
Novelty:  0.0011807
Score:  0.617
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
4
1.1
83.2
leukocyte count
1
1
1
76.5
neutrophil count
1
1
1
73.1
asthma
2
2
0
1.1
71
vitamin D measurement
1
2
2
67.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
83.2
leukocyte count
1
76.5
neutrophil count
1
73.1
asthma
0
1.1
71
vitamin D measurement
2
67.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CUGBP Elav-like family member 3
VGNC:8244
469485
Macaque
CUGBP Elav-like family member 3
716884
Mouse
MGI:1926034
78784
Rat
RGD:1563168
499669
Dog
CUGBP Elav-like family member 3
VGNC:39095
100856524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CUGBP Elav-like family member 3
Macaque
CUGBP Elav-like family member 3
Mouse
Rat
Dog
CUGBP Elav-like family member 3
Publication Statistics
PubMed Score 69.44
PubMed score by year
PubTator Score 43.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title