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Tbio
CELF2
CUGBP Elav-like family member 2

Protein Summary
Description
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostagla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399850
  • ENSP00000382743
  • ENSG00000048740
  • ENST00000416382
  • ENSP00000406451
  • ENST00000417956
  • ENSP00000404834
  • ENST00000608830
  • ENSP00000476999
  • ENST00000631460
  • ENSP00000488582
  • ENST00000632728
  • ENSP00000487802
  • ENST00000638035
  • ENSP00000490401

Symbol
  • BRUNOL3
  • CUGBP2
  • ETR3
  • NAPOR
  • ETR3
  • ETR-3
  • NAPOR
  • CELF-2
  • CUGBP2
  • BRUNOL3
  • CUG-BP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.95
trait
0.93
interacting protein
0.92
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.3   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.3   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0