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Tbio
CELF1
CUGBP Elav-like family member 1

Protein Summary
Description
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310513
  • ENSP00000308386
  • ENSG00000149187
  • ENST00000358597
  • ENSP00000351409
  • ENST00000361904
  • ENSP00000354639
  • ENST00000395290
  • ENSP00000378705
  • ENST00000395292
  • ENSP00000378706
  • ENST00000532048
  • ENSP00000435926

Symbol
  • BRUNOL2
  • CUGBP
  • CUGBP1
  • NAB50
  • CUGBP
  • NAB50
  • NAPOR
  • CUG-BP
  • CUGBP1
  • hNab50
  • BRUNOL2
  • EDEN-BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
disease perturbation
0.79
interacting protein
0.79
transcription factor
0.79
transcription factor binding site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.4   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.4   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0