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Tbio
CELA3B
Chymotrypsin-like elastase family member 3B

Protein Summary
Description
Efficient protease with alanine specificity but only little elastolytic activity. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337107
  • ENSP00000338369
  • ENSG00000219073

Symbol
  • ELA3B
  • CBPP
  • ELA3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
gene perturbation
0.59
protein domain
0.58
disease
0.56
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.65   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 663   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.65   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 663   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
CPA1
Tchem
Family:  Enzyme
Novelty:  0.00601525
Score:  0.979
Data Source:  STRINGDB
CPB1
Tchem
Family:  Enzyme
Novelty:  0.00108031
Score:  0.913
Data Source:  STRINGDB
CEL
Tchem
Family:  Enzyme
Novelty:  0.00156761
Score:  0.882
Data Source:  STRINGDB
CTRL
Tchem
Family:  Enzyme
Novelty:  0.00045495
Score:  0.862
Data Source:  STRINGDB
SYCN
Tbio
Novelty:  0.0354405
Score:  0.825
Data Source:  STRINGDB
CTRC
Tchem
Family:  Enzyme
Novelty:  0.00457428
Score:  0.819
Data Source:  STRINGDB
PNLIPRP1
Tbio
Family:  Enzyme
Novelty:  0.04756238
Score:  0.765
Data Source:  STRINGDB
CLPS
Tbio
Family:  Enzyme
Novelty:  0.00246852
Score:  0.716
Data Source:  STRINGDB
RASA4
Tbio
Family:  Enzyme
Novelty:  0.07418055
Score:  0.709
Data Source:  STRINGDB
PNLIP
Tclin
Family:  Enzyme
Novelty:  0.00043254
Score:  0.706
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.1
76.4
heel bone mineral density
1
1
1
74.8
monocyte percentage of leukocytes
1
1
1
69.5
myeloid white cell count
1
1
1
64.4
BMI-adjusted hip circumference
1
2
2
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
76.4
heel bone mineral density
1
74.8
monocyte percentage of leukocytes
1
69.5
myeloid white cell count
1
64.4
BMI-adjusted hip circumference
2
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915118
67868
Rat
RGD:1307819
298567
Dog
proproteinase E
478196
Horse
chymotrypsin-like elastase family member 3B
100071692
Cow
chymotrypsin-like elastase family, member 3B
281752
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
proproteinase E
Horse
chymotrypsin-like elastase family member 3B
Cow
chymotrypsin-like elastase family, member 3B
Publication Statistics
PubMed Score 244.65
PubMed score by year
PubTator Score 143.69
PubTator score by year
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Related Publications
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PMID
Year
Title