You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CELA3A
Chymotrypsin-like elastase family member 3A

Protein Summary
Description
Efficient protease with alanine specificity but only little elastolytic activity. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290122
  • ENSP00000290122
  • ENSG00000142789

Symbol
  • ELA3
  • ELA3A
  • ELA3
  • ELA3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell type or tissue
0.51
tissue
0.51
cell line
0.48
biological term
0.33


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.998329841
p_ni:  0.001670159
Score:  0.169
Data Source:  BioPlex,STRINGDB
TROAP
Tbio
Novelty:  0.06268103
p_int:  0.96041028
p_ni:  0.039556316
p_wrong:  0.000033404
Score:  0.177
Data Source:  BioPlex,STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.952749045
p_ni:  0.047214775
p_wrong:  0.00003618
Data Source:  BioPlex
HELZ
Tbio
Family:  Enzyme
Novelty:  0.08786982
p_int:  0.940751373
p_ni:  0.059248627
Score:  0.169
Data Source:  BioPlex,STRINGDB
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.897132468
p_ni:  0.102867525
p_wrong:  7e-9
Data Source:  BioPlex
PPIP5K2
Tchem
Family:  Enzyme
Novelty:  0.0284462
p_int:  0.892119452
p_ni:  0.107754818
p_wrong:  0.000125729
Score:  0.219
Data Source:  BioPlex,STRINGDB
PCSK5
Tchem
Family:  Enzyme
Novelty:  0.00070772
p_int:  0.877836054
p_ni:  0.121823473
p_wrong:  0.000340474
Score:  0.18
Data Source:  BioPlex,STRINGDB
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.874679149
p_ni:  0.125320851
Data Source:  BioPlex
FBXO7
Tbio
Novelty:  0.01151907
p_int:  0.874558965
p_ni:  0.075973815
p_wrong:  0.04946722
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.819339409
p_ni:  0.180660591
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
78.7
heel bone mineral density
1
1
1
74.8
monocyte percentage of leukocytes
1
1
1
69.5
myeloid white cell count
1
1
1
64.4
BMI-adjusted hip circumference
1
2
2
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
78.7
heel bone mineral density
1
74.8
monocyte percentage of leukocytes
1
69.5
myeloid white cell count
1
64.4
BMI-adjusted hip circumference
2
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:1307819
298567
Cow
chymotrypsin-like elastase family, member 3B
281752
Opossum
chymotrypsin-like elastase family member 3B
100026235
Anole lizard
proproteinase E
100556283
Species
Name
OMA
EggNOG
Inparanoid
Rat
Cow
chymotrypsin-like elastase family, member 3B
Opossum
chymotrypsin-like elastase family member 3B
Anole lizard
proproteinase E
Publication Statistics
PubMed Score 22.59
PubMed score by year
PubTator Score 25.94
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title