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Tdark
CELA2B
Chymotrypsin-like elastase family member 2B

Protein Summary
Description
Acts upon elastin. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375910
  • ENSP00000365075
  • ENSG00000215704

Symbol
  • ELA2B
  • ELA2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.87
cell line
0.62
cell type or tissue
0.61
protein domain
0.58
tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
NBN
Tbio
Novelty:  0.00759456
p_int:  0.999996816
p_ni:  0.000003183
p_wrong:  1e-9
Score:  0.248
Data Source:  BioPlex,STRINGDB
RPUSD2
Tdark
Family:  Enzyme
Novelty:  1.41606982
p_int:  0.999992739
p_ni:  0.00000726
Score:  0.228
Data Source:  BioPlex,STRINGDB
MRM2
Tbio
Family:  Enzyme
Novelty:  0.06394065
p_int:  0.999862532
p_ni:  0.000137461
p_wrong:  7e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.997925516
p_ni:  0.002072321
p_wrong:  0.000002163
Score:  0.181
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
p_int:  0.995715315
p_ni:  0.004284685
Score:  0.542
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.995517529
p_ni:  0.004482471
Data Source:  BioPlex
MRE11
Tbio
Novelty:  0.01038348
p_int:  0.993764569
p_ni:  0.006235431
Score:  0.253
Data Source:  BioPlex,STRINGDB
ATXN2
Tbio
Novelty:  0.00373116
p_int:  0.991891199
p_ni:  0.0081088
Data Source:  BioPlex
RAD50
Tbio
Novelty:  0.02161298
p_int:  0.989716605
p_ni:  0.010283395
Score:  0.169
Data Source:  BioPlex,STRINGDB
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.966149092
p_ni:  0.000016436
p_wrong:  0.033834472
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
7
6
8.2
94.6
urate measurement
3
4
4
92.5
1
5
0
1.6
91.3
creatinine measurement
4
4
4
84.3
body mass index
2
3
3
54.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
8.2
94.6
urate measurement
4
92.5
0
1.6
91.3
creatinine measurement
4
84.3
body mass index
3
54.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95316
13706
Opossum
chymotrypsin-like elastase family member 2A
100027354
Chicken
chymotrypsin like elastase family member 2A
CGNC:51012
419486
Zebrafish
ZDB-GENE-041117-1
403061
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Opossum
chymotrypsin-like elastase family member 2A
Chicken
chymotrypsin like elastase family member 2A
Zebrafish
Publication Statistics
PubMed Score 2.16
PubMed score by year
PubTator Score 1.78
PubTator score by year
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Related Publications
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PMID
Year
Title