Tchem CEL Bile salt-activated lipase

Protein Summary

Description

Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P19835
• Q16398
• Q5T7U7
• Q9UCH1
• Q9UP41
• BAL

Gene Name

• CEL

Ensembl ID

• ENST00000351304
• ENSP00000342217
• ENSG00000170835

Symbol

• BAL
• BAL
• FAP
• BSDL
• BSSL
• CELL
• FAPP
• LIPA
• CEase
• MODY8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
gene perturbation	0.93
cellular component	0.75
disease perturbation	0.74
small molecule perturbation	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 735.02   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 735.02   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0