Protein Summary
Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
- ENST00000351304
- ENSP00000342217
- ENSG00000170835
- BAL
- BAL
- FAP
- BSDL
- BSSL
- CELL
- FAPP
- LIPA
- CEase
- MODY8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 1 | ||
gene perturbation | 0.93 | ||
cellular component | 0.75 | ||
disease perturbation | 0.74 | ||
small molecule perturbation | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 606.56 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 606.56 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (5)
Protein-Protein Interactions (95)
Nearest Tclin Targets (5)
Upstream (3)
Downstream (2)
1 – 3 of 3
Pathways (9)
Reactome (3)
KEGG (5)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Digestion | ||||
Reactome | Digestion and absorption | ||||
Reactome | Digestion of dietary lipid | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Digestion | ||||
Digestion and absorption | ||||
Digestion of dietary lipid | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (8)
Components (8)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 9 | 13 | 98.4 | |||||
mean platelet volume | 4 | 4 | 6 | 98.4 | |||||
platelet count | 3 | 4 | 5 | 98.1 | |||||
eosinophil percentage of leukocytes | 2 | 7 | 10 | 97.4 | |||||
red blood cell distribution width | 3 | 4 | 6 | 97.2 | |||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 13 | 98.4 | |||||
mean platelet volume | 6 | 98.4 | |||||
platelet count | 5 | 98.1 | |||||
eosinophil percentage of leukocytes | 10 | 97.4 | |||||
red blood cell distribution width | 6 | 97.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:88374 | 12613 | ||||||
Rat | RGD:2331 | 24254 | ||||||
Dog | carboxyl ester lipase | VGNC:39091 | 491280 | |||||
Horse | carboxyl ester lipase | VGNC:16384 | 100066592 | |||||
Cow | carboxyl ester lipase | VGNC:27165 | 280748 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | carboxyl ester lipase | |||||
Horse | carboxyl ester lipase | |||||
Cow | carboxyl ester lipase | |||||
Publication Statistics
PubMed Score 606.56
PubMed score by year
PubTator Score 542.33
PubTator score by year
Related Publications
Text Mined References (77)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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