Tchem CECR2 Cat eye syndrome critical region protein 2

Protein Summary

Description

Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (PubMed:15640247, PubMed:26365797, PubMed:22464331). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465). This gene encodes a bromodomain-containing protein that is involved in chromatin remodeling, and may additionally play a role in DNA damage response. The encoded protein functions as part of an ATP-dependent complex that is involved in neurulation. This gene is a candidate gene for Cat Eye Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• Q9BXF3
• A8MS90
• A8MX16
• Q658Z4
• Q96P58
• Q9C0C3

Gene Name

• CECR2

Ensembl ID

• ENST00000342247
• ENSP00000341219
• ENSG00000099954

Symbol

• KIAA1740

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.68
microRNA	0.65
ligand (protein) perturbation	0.59
cellular component	0.56
biological process	0.54

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Reader / Bromodomain / Cat Eye Syndrome Critical Region Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.81   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 71

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0