Tbio CEBPD CCAAT/enhancer-binding protein delta

Protein Summary

Description

Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P49716
• Q14937
• Q2M2X9
• C/EBP delta

Gene Name

• CEBPD

Ensembl ID

• ENST00000408965
• ENSP00000386165
• ENSG00000221869

Symbol

• CELF
• CRP3
• C/EBP-delta
• NF-IL6-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
gene perturbation	0.96
disease perturbation	0.93
PubMedID	0.93
kinase perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Ccaat/enhancer-binding Protein Delta

Protein / Nucleic Acid Binding / Ccaat/enhancer-binding Protein Delta

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Ccaat/enhancer-binding Protein Delta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.83   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.83   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0