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Tbio
CEACAM5
Carcinoembryonic antigen-related cell adhesion molecule 5

Protein Summary
Description
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a C ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221992
  • ENSP00000221992
  • ENSG00000105388
  • ENST00000398599
  • ENSP00000381600
  • ENST00000405816
  • ENSP00000385072

Symbol
  • CEA
  • CEA
  • CD66e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.86
cell type or tissue
0.85
protein domain
0.85
small molecule perturbation
0.75
cellular component
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12771.89   (req: < 5)
Gene RIFs: 185   (req: <= 3)
Antibodies: 2952   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12771.89   (req: >= 5)
Gene RIFs: 185   (req: > 3)
Antibodies: 2952   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (178)
MSLN
Tbio
Novelty:  0.00191245
Score:  0.962
Data Source:  STRINGDB
PSCA
Tbio
Novelty:  0.00323778
Score:  0.933
Data Source:  STRINGDB
GPLD1
Tbio
Family:  Enzyme
Novelty:  0.00627091
Score:  0.923
Data Source:  STRINGDB
CEACAM7
Tbio
Novelty:  0.05266788
Score:  0.92
Data Source:  STRINGDB
AFP
Tbio
Novelty:  0.00004755
Score:  0.92
Data Source:  STRINGDB
LY6K
Tbio
Novelty:  0.01861325
Score:  0.917
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.917
Data Source:  STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
Score:  0.916
Data Source:  STRINGDB
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
Score:  0.913
Data Source:  STRINGDB
CD52
Tclin
Novelty:  0.00142013
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum carcinoembryonic antigen measurement
1
5
5
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum carcinoembryonic antigen measurement
5
99.1
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carcinoembryonic antigen related cell adhesion molecule 5
VGNC:13312
456062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carcinoembryonic antigen related cell adhesion molecule 5
Publication Statistics
PubMed Score 12771.89
PubMed score by year
PubTator Score 341.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title