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Tbio
CEACAM3
Carcinoembryonic antigen-related cell adhesion molecule 3

Protein Summary
Description
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344550
  • ENSP00000341725
  • ENSG00000170956
  • ENST00000357396
  • ENSP00000349971
  • ENST00000415495
  • ENSP00000411641
  • ENST00000630848
  • ENSP00000485920

Symbol
  • CD66D
  • CGM1
  • CEA
  • CGM1
  • W264
  • W282
  • CD66D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
cell line
0.57
gene perturbation
0.53
cellular component
0.47
tissue sample
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.45   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.45   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
CEACAM1
Tbio
Novelty:  0.0029954
Score:  0.943
Data Source:  STRINGDB
CLEC4D
Tbio
Novelty:  0.04119682
Score:  0.93
Data Source:  STRINGDB
MCEMP1
Tdark
Novelty:  0.14180782
Score:  0.93
Data Source:  STRINGDB
CLEC12A
Tbio
Novelty:  0.01478908
Score:  0.93
Data Source:  STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
Score:  0.929
Data Source:  STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.926
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.923
Data Source:  STRINGDB
HVCN1
Tchem
Family:  IC
Novelty:  0.00195009
Score:  0.918
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.917
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum carcinoembryonic antigen measurement
1
5
5
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum carcinoembryonic antigen measurement
5
99.1
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
carcinoembryonic antigen-related cell adhesion molecule 24
100049000
Species
Name
OMA
EggNOG
Inparanoid
Dog
carcinoembryonic antigen-related cell adhesion molecule 24
Publication Statistics
PubMed Score 41.45
PubMed score by year
PubTator Score 8979.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title