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Tbio
CEACAM16
Carcinoembryonic antigen-related cell adhesion molecule 16

Protein Summary
Description
Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane. The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405314
  • ENSP00000385576
  • ENSG00000213892
  • ENST00000587331
  • ENSP00000466561

Symbol
  • CEAL2
  • CEAL2
  • DFNA4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.64
cell type or tissue
0.63
tissue
0.48
disease
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.22   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.22   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
TSPEAR
Tbio
Novelty:  0.15908638
Score:  0.856
Data Source:  STRINGDB
SMPX
Tbio
Novelty:  0.05084864
Score:  0.834
Data Source:  STRINGDB
TPRN
Tbio
Novelty:  0.05784581
Score:  0.829
Data Source:  STRINGDB
GPSM2
Tbio
Novelty:  0.00941766
Score:  0.765
Data Source:  STRINGDB
TECTB
Tbio
Novelty:  0.04489491
Score:  0.762
Data Source:  STRINGDB
ZNF574
Tdark
Family:  TF
Novelty:  2.72596185
Score:  0.714
Data Source:  STRINGDB
TMEM145
Tdark
Novelty:  2.30428448
Score:  0.707
Data Source:  STRINGDB
PAFAH1B3
Tbio
Family:  Enzyme
Novelty:  0.10517347
Score:  0.692
Data Source:  STRINGDB
OTOG
Tdark
Novelty:  0.04344519
Score:  0.683
Data Source:  STRINGDB
OTOGL
Tbio
Novelty:  0.11538923
Score:  0.676
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
21
21
100
low density lipoprotein cholesterol measurement
5
19
24
8
99.9
total cholesterol measurement
2
15
19
99.9
2
14
0
6.8
98.7
family history of Alzheimer’s disease
1
12
0
7.9
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
21
100
low density lipoprotein cholesterol measurement
24
8
99.9
total cholesterol measurement
19
99.9
0
6.8
98.7
family history of Alzheimer’s disease
0
7.9
98.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carcinoembryonic antigen related cell adhesion molecule 16
VGNC:11960
456116
Mouse
MGI:2685615
330483
Rat
RGD:1306386
292700
Dog
carcinoembryonic antigen related cell adhesion molecule 16
VGNC:39087
484457
Horse
carcinoembryonic antigen related cell adhesion molecule 16
VGNC:16380
100070583
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carcinoembryonic antigen related cell adhesion molecule 16
Mouse
Rat
Dog
carcinoembryonic antigen related cell adhesion molecule 16
Horse
carcinoembryonic antigen related cell adhesion molecule 16
Publication Statistics
PubMed Score 11.22
PubMed score by year
PubTator Score 14.10
PubTator score by year
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Related Publications
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PMID
Year
Title