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Tbio
CEACAM1
Carcinoembryonic antigen-related cell adhesion molecule 1

Protein Summary
Description
Isoform 1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000161559
  • ENSP00000161559
  • ENSG00000079385
  • ENST00000352591
  • ENSP00000244291
  • ENST00000358394
  • ENSP00000351165
  • ENST00000403444
  • ENSP00000384709
  • ENST00000403461
  • ENSP00000384083
  • ENST00000599389
  • ENSP00000471918

Symbol
  • BGP
  • BGP1
  • BGP
  • BGP1
  • BGPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
PubMedID
0.99
biological term
0.93
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.39   (req: < 5)
Gene RIFs: 189   (req: <= 3)
Antibodies: 828   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.39   (req: >= 5)
Gene RIFs: 189   (req: > 3)
Antibodies: 828   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
CEACAM3
Tbio
Novelty:  0.02597577
Score:  0.943
Data Source:  STRINGDB
CD300A
Tbio
Novelty:  0.01745189
Score:  0.941
Data Source:  STRINGDB
HVCN1
Tchem
Family:  IC
Novelty:  0.00195009
Score:  0.94
Data Source:  STRINGDB
CEACAM8
Tbio
Novelty:  0.00370138
Score:  0.937
Data Source:  Reactome,STRINGDB
CD177
Tbio
Novelty:  0.00197563
Score:  0.933
Data Source:  STRINGDB
LAIR1
Tbio
Novelty:  0.0133817
Score:  0.929
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.927
Data Source:  STRINGDB
PTAFR
Tchem
Family:  GPCR
Novelty:  0.00755426
Score:  0.925
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.921
Data Source:  STRINGDB
MS4A3
Tbio
Novelty:  0.05521485
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Fibronectin matrix formation
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Extracellular matrix organization
Fibronectin matrix formation
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (65)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
84.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
84.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carcinoembryonic antigen related cell adhesion molecule 1
456078
Mouse
MGI:1347246
26367
Rat
RGD:67396
81613
Dog
carcinoembryonic antigen related cell adhesion molecule 1
612435
Horse
carcinoembryonic antigen-related cell adhesion molecule 1
100069287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carcinoembryonic antigen related cell adhesion molecule 1
Mouse
Rat
Dog
carcinoembryonic antigen related cell adhesion molecule 1
Horse
carcinoembryonic antigen-related cell adhesion molecule 1
Publication Statistics
PubMed Score 445.39
PubMed score by year
PubTator Score 365.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title