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Tbio
CEACAM1
Carcinoembryonic antigen-related cell adhesion molecule 1

Protein Summary
Description
Isoform 1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000161559
  • ENSP00000161559
  • ENSG00000079385
  • ENST00000352591
  • ENSP00000244291
  • ENST00000358394
  • ENSP00000351165
  • ENST00000403444
  • ENSP00000384709
  • ENST00000403461
  • ENSP00000384083
  • ENST00000599389
  • ENSP00000471918

Symbol
  • BGP
  • BGP1
  • BGP
  • BGP1
  • BGPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
PubMedID
0.99
biological term
0.93
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.18   (req: < 5)
Gene RIFs: 189   (req: <= 3)
Antibodies: 828   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.18   (req: >= 5)
Gene RIFs: 189   (req: > 3)
Antibodies: 828   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0