You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CDYL
Chromodomain Y-like protein

Protein Summary
Description
Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328908
  • ENSP00000330512
  • ENSG00000153046
  • ENST00000343762
  • ENSP00000340908
  • ENST00000397588
  • ENSP00000380718
  • ENST00000449732
  • ENSP00000394076

Symbol
  • CDYL1
  • CDYL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
co-expressed gene
0.85
protein domain
0.85
virus perturbation
0.76
PubMedID
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.78   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.78   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (137)
CYBRD1
Tbio
Family:  Enzyme
Novelty:  0.01128708
p_int:  1
Score:  0.871
Data Source:  BioPlex,STRINGDB
MIER2
Tbio
Novelty:  0.85226416
p_int:  1
Score:  0.613
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.999993416
p_ni:  0.000006584
Score:  0.16
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999980048
p_ni:  0.000019952
Score:  0.418
Data Source:  BioPlex,STRINGDB
MIER1
Tbio
Novelty:  0.00357772
p_int:  0.999972165
p_ni:  0.000027835
Score:  0.921
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.99992028
p_ni:  0.00007972
Score:  0.359
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999514745
p_ni:  0.000485255
Score:  0.685
Data Source:  BioPlex,STRINGDB
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.986230096
p_ni:  0.013763466
p_wrong:  0.000006437
Score:  0.15
Data Source:  BioPlex,STRINGDB
EFNB3
Tbio
Novelty:  0.0120367
p_int:  0.986117143
p_ni:  0.01388278
p_wrong:  7.6e-8
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.984164128
p_ni:  0.015835872
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
59.9
1
1
0
1.1
29
keratinocyte carcinoma
1
1
0
1.1
13.5
1
1
0
1.1
13.1
response to ketogenic diet
1
1
0
13.5
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
59.9
0
1.1
29
keratinocyte carcinoma
0
1.1
13.5
0
1.1
13.1
response to ketogenic diet
0
13.5
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromodomain Y like
VGNC:52151
462408
Macaque
chromodomain Y like
722957
Mouse
MGI:1339956
12593
Rat
RGD:1549745
361237
Dog
chromodomain Y like
478708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromodomain Y like
Macaque
chromodomain Y like
Mouse
Rat
Dog
chromodomain Y like
Publication Statistics
PubMed Score 36.78
PubMed score by year
PubTator Score 9.97
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title