CDX2
Homeobox protein CDX-2
Protein Summary
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
- ENST00000381020
- ENSP00000370408
- ENSG00000165556
- CDX3
- CDX3
- CDX-3
- CDX2/AS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.86 | ||
biological process | 0.85 | ||
protein domain | 0.85 | ||
biological term | 0.78 | ||
cell type or tissue | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1335.35 (req: < 5)
Gene RIFs: 274 (req: <= 3)
Antibodies: 984 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1335.35 (req: >= 5)
Gene RIFs: 274 (req: > 3)
Antibodies: 984 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (213)
Nearest Tclin Targets
Pathways (15)
Reactome (7)
KEGG (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Incretin synthesis, secretion, and inactivation | ||||
Reactome | Metabolism of proteins | ||||
Reactome | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | ||||
Reactome | Peptide hormone metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Incretin synthesis, secretion, and inactivation | ||||
Metabolism of proteins | ||||
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | ||||
Peptide hormone metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (7)
Components (4)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 6 | 7 | 99.5 | |||||
monocyte count | 4 | 6 | 7 | 99.4 | |||||
serum gamma-glutamyl transferase measurement | 2 | 4 | 4 | 97.3 | |||||
leukocyte count | 2 | 3 | 4 | 97.2 | |||||
granulocyte percentage of myeloid white cells | 1 | 2 | 2 | 95.5 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 7 | 99.5 | |||||
monocyte count | 7 | 99.4 | |||||
serum gamma-glutamyl transferase measurement | 4 | 97.3 | |||||
leukocyte count | 4 | 97.2 | |||||
granulocyte percentage of myeloid white cells | 2 | 95.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | caudal type homeobox 2 | VGNC:13071 | 467350 | |||||
Mouse | MGI:88361 | 12591 | ||||||
Rat | RGD:621234 | 66019 | ||||||
Dog | caudal type homeobox 2 | VGNC:39085 | 486028 | |||||
Horse | caudal type homeobox 2 | VGNC:51937 | 100051406 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | caudal type homeobox 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | caudal type homeobox 2 | |||||
Horse | caudal type homeobox 2 | |||||
Publication Statistics
PubMed Score 1335.35
PubMed score by year
PubTator Score 720.76
PubTator score by year
Related Publications
Text Mined References (295)
GeneRif Annotations (274)
Items per page:
0 of 0
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