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Tbio
CDT1
DNA replication factor Cdt1

Protein Summary
Description
Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301019
  • ENSP00000301019
  • ENSG00000167513

Symbol
  • DUP
  • RIS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.9
transcription factor binding site profile
0.83
histone modification site profile
0.77
hub protein
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.42   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.42   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (293)
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999999982
p_ni:  1.6e-8
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999999853
p_ni:  1.46e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.999999671
p_ni:  3.29e-7
Score:  0.933
Data Source:  BioPlex,STRINGDB
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.999995338
p_ni:  0.000004662
Score:  0.749
Data Source:  BioPlex,STRINGDB
CKS2
Tbio
Family:  Enzyme
Novelty:  0.02482411
p_int:  0.999885365
p_ni:  0.000114596
p_wrong:  3.9e-8
Score:  0.911
Data Source:  BioPlex,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
p_int:  0.998630143
p_ni:  0.001320007
p_wrong:  0.00004985
Score:  0.99
Data Source:  BioPlex,STRINGDB
MCM4
Tchem
Novelty:  0.00604311
Score:  0.999
Data Source:  STRINGDB
MCM3
Tbio
Novelty:  0.00593382
Score:  0.999
Data Source:  STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.999
Data Source:  STRINGDB
MCM6
Tbio
Novelty:  0.00675724
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
CDT1 association with the CDC6:ORC:origin complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Cell Cycle
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
5
9
10
99.3
HbA1c measurement
6
11
12
98.9
mean corpuscular hemoglobin concentration
7
5
9
98.2
reticulocyte count
6
9
16
97.7
hematocrit
4
6
7
97.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
10
99.3
HbA1c measurement
12
98.9
mean corpuscular hemoglobin concentration
9
98.2
reticulocyte count
16
97.7
hematocrit
7
97.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromatin licensing and DNA replication factor 1
VGNC:5723
468072
Macaque
chromatin licensing and DNA replication factor 1
711530
Mouse
MGI:1914427
67177
Rat
RGD:1309211
292071
Dog
chromatin licensing and DNA replication factor 1
VGNC:39083
479616
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromatin licensing and DNA replication factor 1
Macaque
chromatin licensing and DNA replication factor 1
Mouse
Rat
Dog
chromatin licensing and DNA replication factor 1
Publication Statistics
PubMed Score 256.42
PubMed score by year
PubTator Score 170.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title