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Tbio
CDSN
Corneodesmosin

Protein Summary
Description
Important for the epidermal barrier integrity. This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.79
cellular component
0.67
protein complex
0.65
trait
0.61
disease
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (185)
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.98507011
p_ni:  0.01492989
Score:  0.191
Data Source:  BioPlex,STRINGDB
CFAP298
Tbio
Novelty:  0.1550579
p_int:  0.984248676
p_ni:  0.015751324
Score:  0.183
Data Source:  BioPlex,STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.973629534
p_ni:  0.026370466
Score:  0.179
Data Source:  BioPlex,STRINGDB
OR2L13
Tdark
Family:  oGPCR
Novelty:  0.3071575
p_int:  0.964969244
p_ni:  0.035029852
p_wrong:  9.04e-7
Data Source:  BioPlex
VAV1
Tchem
Novelty:  0.00180518
p_int:  0.946270634
p_ni:  0.053729349
p_wrong:  1.7e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
CHCHD5
Tbio
Novelty:  0.16304141
p_int:  0.943525082
p_ni:  0.0564677
p_wrong:  0.000007219
Data Source:  BioPlex
GPATCH2L
Tdark
Novelty:  1.68490464
p_int:  0.866019833
p_ni:  0.133770955
p_wrong:  0.000209212
Score:  0.189
Data Source:  BioPlex,STRINGDB
C1orf146
Tdark
Novelty:  6.67972686
p_int:  0.842627619
p_ni:  0.157274728
p_wrong:  0.000097653
Data Source:  BioPlex
MMRN1
Tbio
Novelty:  0.03378128
p_int:  0.79116694
p_ni:  0.208830585
p_wrong:  0.000002475
Score:  0.21
Data Source:  BioPlex,STRINGDB
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.767670789
p_ni:  0.232327292
p_wrong:  0.000001919
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (231)
Items per page:
1 – 5 of 231
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
5
0
2.8
97.6
1
5
0
2.8
97.6
1
5
0
2.8
97.6
8
5
1
1
95.3
8
5
1
1
95.3
Items per page:
1 – 5 of 231
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.8
97.6
0
2.8
97.6
0
2.8
97.6
1
1
95.3
1
1
95.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
corneodesmosin
714553
Mouse
MGI:3505689
386463
Dog
corneodesmosin
VGNC:39082
607062
Horse
corneodesmosin
VGNC:16376
100054766
Cow
corneodesmosin
VGNC:27157
522351
Species
Name
OMA
EggNOG
Inparanoid
Macaque
corneodesmosin
Mouse
Dog
corneodesmosin
Horse
corneodesmosin
Cow
corneodesmosin
Publication Statistics
PubMed Score 107.00
PubMed score by year
PubTator Score 106.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title