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Tbio
CDS1
Phosphatidate cytidylyltransferase 1

Protein Summary
Description
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells. Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum wh ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295887
  • ENSP00000295887
  • ENSG00000163624

Symbol
  • CDS
  • CDS 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
PubMedID
0.91
metabolite
0.83
histone modification site profile
0.81
kinase
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.81   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.81   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999999275
p_ni:  7.1e-7
p_wrong:  1.4e-8
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999997523
p_ni:  0.000002477
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999799423
p_ni:  0.000200577
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999794739
p_ni:  0.000203177
p_wrong:  0.000002083
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.999365322
p_ni:  0.000634672
p_wrong:  6e-9
Data Source:  BioPlex
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.999157954
p_ni:  0.000842043
p_wrong:  2e-9
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.992594422
p_ni:  0.007301684
p_wrong:  0.000103894
Data Source:  BioPlex
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.989964357
p_ni:  0.010035642
p_wrong:  1e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
TSPAN6
Tbio
Novelty:  0.11515803
p_int:  0.971129413
p_ni:  0.002409752
p_wrong:  0.026460836
Score:  0.173
Data Source:  BioPlex,STRINGDB
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.838535718
p_ni:  0.006782109
p_wrong:  0.154682173
Data Source:  BioPlex
Pathways (11)
Glycerophospholipid biosynthesis (R-HSA-1483206)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PI
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PI
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDP-diacylglycerol synthase 1
VGNC:2025
461202
Macaque
CDP-diacylglycerol synthase 1
706649
Mouse
MGI:1921846
74596
Rat
RGD:621185
81925
Dog
CDP-diacylglycerol synthase 1
VGNC:39080
487840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDP-diacylglycerol synthase 1
Macaque
CDP-diacylglycerol synthase 1
Mouse
Rat
Dog
CDP-diacylglycerol synthase 1
Publication Statistics
PubMed Score 13.81
PubMed score by year
PubTator Score 390.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title