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Tbio
CDO1
Cysteine dioxygenase type 1

Protein Summary
Description
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250535
  • ENSP00000250535
  • ENSG00000129596

Symbol
  • CDO-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
disease perturbation
0.74
PubMedID
0.69
biological process
0.68
histone modification site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.93   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.93   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
LRRC58
Tdark
Novelty:  2.4415805
p_int:  0.999999934
p_ni:  5.4e-8
p_wrong:  1.2e-8
Score:  0.342
Data Source:  BioPlex,STRINGDB
MTMR4
Tbio
Family:  Enzyme
Novelty:  0.09166984
p_int:  0.999747035
p_ni:  0.000252965
Score:  0.165
Data Source:  BioPlex,STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.987468197
p_ni:  0.012531588
p_wrong:  2.15e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
RERE
Tbio
Family:  TF
Novelty:  0.03065098
p_int:  0.983084257
p_ni:  0.000888562
p_wrong:  0.016027181
Score:  0.29
Data Source:  BioPlex,STRINGDB
TOPBP1
Tbio
Family:  Enzyme
Novelty:  0.00735579
p_int:  0.93514179
p_ni:  0.000039136
p_wrong:  0.064819074
Score:  0.29
Data Source:  BioPlex,STRINGDB
TXNRD1
Tclin
Family:  Enzyme
Novelty:  0.00299018
p_int:  0.890151199
p_ni:  0.109848801
Score:  0.43
Data Source:  BioPlex,STRINGDB
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
p_int:  0.880450963
p_ni:  0.119549024
p_wrong:  1.3e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
CSAD
Tbio
Family:  Enzyme
Novelty:  0.01293688
Score:  0.96
Data Source:  STRINGDB
GADL1
Tbio
Family:  Enzyme
Novelty:  0.018813
Score:  0.956
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
1
0
2.4
24.2
alkaline phosphatase measurement
2
1
1
6.6
17
intraocular pressure measurement
1
1
1
10.1
BMI-adjusted hip circumference
1
1
1
4.3
BMI-adjusted waist circumference
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.4
24.2
alkaline phosphatase measurement
1
6.6
17
intraocular pressure measurement
1
10.1
BMI-adjusted hip circumference
1
4.3
BMI-adjusted waist circumference
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine dioxygenase type 1
VGNC:3944
462010
Mouse
MGI:105925
12583
Rat
RGD:69262
81718
Dog
cysteine dioxygenase type 1
VGNC:39075
474637
Horse
cysteine dioxygenase type 1
VGNC:16370
100629132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine dioxygenase type 1
Mouse
Rat
Dog
cysteine dioxygenase type 1
Horse
cysteine dioxygenase type 1
Publication Statistics
PubMed Score 67.93
PubMed score by year
PubTator Score 31.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title