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Tbio
CDKN2D
Cyclin-dependent kinase 4 inhibitor D

Protein Summary
Description
Interacts strongly with CDK4 and CDK6 and inhibits them. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335766
  • ENSP00000337056
  • ENSG00000129355
  • ENST00000393599
  • ENSP00000377224

Symbol
  • p19
  • INK4D
  • p19-INK4D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
virus perturbation
0.83
transcription factor binding site profile
0.74
small molecule perturbation
0.71
transcription factor
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.43   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.43   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
CDC42BPA
Tchem
Family:  Kinase
Novelty:  0.02575412
p_int:  0.999947205
p_ni:  0.000052795
Data Source:  BioPlex
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
p_int:  0.999890392
p_ni:  0.000109608
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PTER
Tbio
Family:  Enzyme
Novelty:  0.01347498
p_int:  0.999633438
p_ni:  0.000366548
p_wrong:  1.4e-8
Data Source:  BioPlex
RBM12
Tbio
Novelty:  0.10430477
p_int:  0.992718172
p_ni:  0.00726891
p_wrong:  0.000012918
Data Source:  BioPlex
MTFP1
Tbio
Novelty:  0.01899273
p_int:  0.990228183
p_ni:  0.009771817
Data Source:  BioPlex
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.949096079
p_ni:  0.050903914
p_wrong:  6e-9
Data Source:  BioPlex
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  0.923602049
p_ni:  0.008367232
p_wrong:  0.068030721
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
RARRES2
Tbio
Novelty:  0.0029178
p_int:  0.858957787
p_ni:  0.14104221
p_wrong:  4e-9
Data Source:  BioPlex
PMCH
Tbio
Novelty:  0.00600873
p_int:  0.85287947
p_ni:  0.147120506
p_wrong:  2.4e-8
Data Source:  BioPlex
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.753089318
p_ni:  0.246910682
p_wrong:  1e-9
Data Source:  BioPlex
Pathways (85)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
1
1.1
96.1
low density lipoprotein cholesterol measurement
3
8
9
95.5
red blood cell distribution width
4
5
6
94
body height
2
2
2
93.6
total cholesterol measurement
2
7
8
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
96.1
low density lipoprotein cholesterol measurement
9
95.5
red blood cell distribution width
6
94
body height
2
93.6
total cholesterol measurement
8
89.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 2D
VGNC:8728
745942
Macaque
cyclin dependent kinase inhibitor 2D
713172
Mouse
MGI:105387
12581
Horse
cyclin dependent kinase inhibitor 2D
VGNC:16367
100057750
Cow
cyclin dependent kinase inhibitor 2D
VGNC:27147
510244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 2D
Macaque
cyclin dependent kinase inhibitor 2D
Mouse
Horse
cyclin dependent kinase inhibitor 2D
Cow
cyclin dependent kinase inhibitor 2D
Publication Statistics
PubMed Score 75.43
PubMed score by year
PubTator Score 64.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title