Tbio CDKN2C Cyclin-dependent kinase 4 inhibitor C

Protein Summary

Description

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42773
• Q8TB83

Gene Name

• CDKN2C

Ensembl ID

• ENST00000262662
• ENSP00000262662
• ENSG00000123080
• ENST00000371761
• ENSP00000360826
• ENST00000396148
• ENSP00000379452

Symbol

• CDKN6
• p18
• INK4C
• p18-INK4C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93
transcription factor binding site profile	0.91
transcription factor	0.8
disease perturbation	0.74
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.56   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 490   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.56   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 490   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0