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Tbio
CDKN2C
Cyclin-dependent kinase 4 inhibitor C

Protein Summary
Description
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262662
  • ENSP00000262662
  • ENSG00000123080
  • ENST00000371761
  • ENSP00000360826
  • ENST00000396148
  • ENSP00000379452

Symbol
  • CDKN6
  • p18
  • INK4C
  • p18-INK4C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
transcription factor binding site profile
0.91
transcription factor
0.8
disease perturbation
0.74
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.99   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 490   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.99   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 490   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
ANKRD44
Tdark
Family:  Enzyme
Novelty:  0.38360979
p_int:  0.999998875
p_ni:  0.000001125
Score:  0.264
Data Source:  BioPlex,STRINGDB
CCND1
Tchem
Novelty:  0.0001186
p_int:  0.999966718
p_ni:  0.000033279
p_wrong:  3e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.999916215
p_ni:  0.000072109
p_wrong:  0.000011676
Score:  0.991
Data Source:  BioPlex,STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
p_int:  0.998779624
p_ni:  0.001214276
p_wrong:  0.0000061
Score:  0.638
Data Source:  BioPlex,STRINGDB
GRP
Tbio
Novelty:  0.00034247
p_int:  0.998634875
p_ni:  0.001152678
p_wrong:  0.000212448
Data Source:  BioPlex
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.998582546
p_ni:  0.0007412
p_wrong:  0.000676254
Data Source:  BioPlex
AVP
Tbio
Novelty:  0.00016475
p_int:  0.998545918
p_ni:  0.00145338
p_wrong:  7.02e-7
Data Source:  BioPlex
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.997050062
p_ni:  0.002944256
p_wrong:  0.000005682
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
6
6
92.4
triglyceride measurement
3
3
3
78.4
body height
2
2
2
77.8
HbA1c measurement
1
1
1
71.3
2
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
92.4
triglyceride measurement
3
78.4
body height
2
77.8
HbA1c measurement
1
71.3
2
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 2C
VGNC:8152
469319
Macaque
cyclin dependent kinase inhibitor 2C
711877
Mouse
MGI:105388
12580
Rat
RGD:2325
54238
Dog
cyclin dependent kinase inhibitor 2C
VGNC:39072
475359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 2C
Macaque
cyclin dependent kinase inhibitor 2C
Mouse
Rat
Dog
cyclin dependent kinase inhibitor 2C
Publication Statistics
PubMed Score 132.99
PubMed score by year
PubTator Score 102.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title