CDKN2B
Cyclin-dependent kinase 4 inhibitor B
Protein Summary
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
- ENST00000276925
- ENSP00000276925
- ENSG00000147883
- ENST00000380142
- ENSP00000369487
- MTS2
- P15
- MTS2
- TP15
- CDK4I
- INK4B
- p15INK4b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.97 | ||
biological term | 0.95 | ||
PubMedID | 0.9 | ||
gene perturbation | 0.87 | ||
disease | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 630.91 (req: < 5)
Gene RIFs: 244 (req: <= 3)
Antibodies: 566 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 630.91 (req: >= 5)
Gene RIFs: 244 (req: > 3)
Antibodies: 566 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (155)
Nearest Tclin Targets (4)
Upstream (3)
Downstream (1)
1 – 3 of 3
Pathways (49)
Reactome (19)
KEGG (10)
PathwayCommons (4)
WikiPathways (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (2)
Components (3)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (66)
Items per page:
1 – 5 of 66
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
16 | 11 | 5 | 1.2 | 99.8 | |||||
cup-to-disc ratio measurement | 4 | 5 | 7 | 98.6 | |||||
10 | 9 | 0 | 1.3 | 98.1 | |||||
5 | 3 | 0 | 1.2 | 97.8 | |||||
8 | 4 | 0 | 1.3 | 96.6 | |||||
Items per page:
1 – 5 of 66
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
5 | 1.2 | 99.8 | |||||
cup-to-disc ratio measurement | 7 | 98.6 | |||||
0 | 1.3 | 98.1 | |||||
0 | 1.2 | 97.8 | |||||
0 | 1.3 | 96.6 | |||||
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IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cyclin dependent kinase inhibitor 2B | 709209 | ||||||
Mouse | MGI:104737 | 12579 | ||||||
Rat | RGD:2324 | 25164 | ||||||
Dog | cyclin dependent kinase inhibitor 2B | 481563 | ||||||
Horse | cyclin-dependent kinase 2B inhibitor | 100034122 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cyclin dependent kinase inhibitor 2B | |||||
Mouse | ||||||
Rat | ||||||
Dog | cyclin dependent kinase inhibitor 2B | |||||
Horse | cyclin-dependent kinase 2B inhibitor | |||||
Publication Statistics
PubMed Score 630.91
PubMed score by year
PubTator Score 1253.14
PubTator score by year
Related Publications
Text Mined References (399)
GeneRif Annotations (244)
Items per page:
0 of 0
PMID | Year | Title |
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