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Tbio
CDKN2AIP
CDKN2A-interacting protein

Protein Summary
Description
Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000504169
  • ENSP00000427108
  • ENSG00000168564

Symbol
  • CARF
  • CARF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
histone modification site profile
0.74
cellular component
0.61
virus perturbation
0.59
protein complex
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
PCF11
Tbio
Novelty:  0.01882626
p_int:  0.999999997
p_ni:  2e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
XRN2
Tbio
Family:  Enzyme
Novelty:  0.01478359
p_int:  0.999932995
p_ni:  0.000067005
Score:  0.966
Data Source:  BioPlex,STRINGDB
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
p_int:  0.999893085
p_ni:  0.00010664
p_wrong:  2.75e-7
Data Source:  BioPlex
E2F4
Tbio
Family:  TF
Novelty:  0.00317412
p_int:  0.999738299
p_ni:  0.00001476
p_wrong:  0.000246941
Data Source:  BioPlex
HNRNPDL
Tbio
Novelty:  0.00222179
p_int:  0.998893963
p_ni:  0.001106036
p_wrong:  1e-9
Score:  0.348
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.998744544
p_ni:  0.001255455
p_wrong:  1e-9
Data Source:  BioPlex
CLP1
Tbio
Family:  Enzyme
Novelty:  0.04643806
p_int:  0.998276643
p_ni:  0.001723357
Score:  0.251
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.987107223
p_ni:  0.008488489
p_wrong:  0.004404288
Data Source:  BioPlex
AKAP11
Tbio
Family:  Enzyme
Novelty:  0.0685826
p_int:  0.985520566
p_ni:  0.014479434
Data Source:  BioPlex
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.984553098
p_ni:  0.015446698
p_wrong:  2.03e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDKN2A interacting protein
VGNC:576
461623
Macaque
CDKN2A interacting protein
701583
Mouse
MGI:1918175
70925
Rat
RGD:1305302
306455
Dog
CDKN2A interacting protein
VGNC:39070
607991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDKN2A interacting protein
Macaque
CDKN2A interacting protein
Mouse
Rat
Dog
CDKN2A interacting protein
Publication Statistics
PubMed Score 11.05
PubMed score by year
PubTator Score 4.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title