Tbio CDKN2AIP CDKN2A-interacting protein

Protein Summary

Description

Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q9NXV6
• Q8TBM5
• Q9NYH0

Gene Name

• CDKN2AIP

Ensembl ID

• ENST00000504169
• ENSP00000427108
• ENSG00000168564

Symbol

• CARF
• CARF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.84
histone modification site profile	0.74
cellular component	0.61
virus perturbation	0.59
protein complex	0.56

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Cdkn2a-interacting Protein

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Cdkn2a-interacting Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0