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Tchem
CDKL5
Cyclin-dependent kinase-like 5

Protein Summary
Description
Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860). May regulate ciliogenesis (PubMed:29420175). This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379989
  • ENSP00000369325
  • ENSG00000008086
  • ENST00000379996
  • ENSP00000369332
  • ENST00000623535
  • ENSP00000485244

Symbol
  • STK9
  • ISSX
  • STK9
  • EIEE2
  • CFAP247
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
virus perturbation
0.92
small molecule
0.85
histone modification site profile
0.81
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.85   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.85   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (108)
DHX38
Tbio
Family:  Enzyme
Novelty:  0.01939445
p_int:  0.968942447
p_ni:  0.030733296
p_wrong:  0.000324257
Score:  0.189
Data Source:  BioPlex,STRINGDB
MACF1
Tbio
Novelty:  0.0166336
p_int:  0.922073245
p_ni:  0.077926755
Score:  0.243
Data Source:  BioPlex,STRINGDB
SERPINB8
Tbio
Novelty:  0.03308357
p_int:  0.920323719
p_ni:  0.079647722
p_wrong:  0.000028559
Score:  0.234
Data Source:  BioPlex,STRINGDB
DHX16
Tbio
Family:  Enzyme
Novelty:  0.02678951
p_int:  0.904067179
p_ni:  0.095932821
Score:  0.234
Data Source:  BioPlex,STRINGDB
GPALPP1
Tdark
Novelty:  13.22858591
p_int:  0.854040145
p_ni:  0.145959835
p_wrong:  1.9e-8
Score:  0.253
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.81383175
p_ni:  0.18616825
Score:  0.363
Data Source:  BioPlex,STRINGDB
HDGFL3
Tbio
Family:  Epigenetic
Novelty:  0.14292821
p_int:  0.763568416
p_ni:  0.22345908
p_wrong:  0.012972504
Score:  0.189
Data Source:  BioPlex,STRINGDB
RABL6
Tbio
Family:  Enzyme
Novelty:  0.11501478
p_int:  0.754775334
p_ni:  0.244970872
p_wrong:  0.000253794
Score:  0.196
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
Score:  0.978
Data Source:  STRINGDB
LRRC4C
Tbio
Novelty:  0.06534005
Score:  0.75
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
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Items per page:
1 – 5 of 27
Data Source
Name
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Explore in Source
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Name
Explore in Pharos
Explore in Source
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HGNC
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
0
6.1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
0
6.1
35
Find similar targets by:
IDG Resources
Chemical Tool
N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(dimethylglycyl)piperidine-4-carboxamide
image for N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(dimethylglycyl)piperidine-4-carboxamide
Details:
  • ChEBI:  143123
  • Provider:  UNC-CH
  • Activity:  190 nM
  • Selectivity:  0.017
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 5
VGNC:6431
473529
Macaque
cyclin dependent kinase like 5
693974
Mouse
MGI:1278336
382253
Rat
RGD:2324133
100362725
Dog
cyclin dependent kinase like 5
VGNC:39067
491761
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 5
Macaque
cyclin dependent kinase like 5
Mouse
Rat
Dog
cyclin dependent kinase like 5
Publication Statistics
PubMed Score 271.85
PubMed score by year
PubTator Score 162.40
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title