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Tdark
CDKL4
Cyclin-dependent kinase-like 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378803
  • ENSP00000368080
  • ENSG00000205111
  • ENST00000395035
  • ENSP00000378476
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cell type or tissue
0.59
protein domain
0.58
PubMedID
0.49
tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
HSP90AB3P
Tdark
p_int:  0.99954705
p_ni:  0.00045295
Data Source:  BioPlex
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999341841
p_ni:  0.000658159
Score:  0.183
Data Source:  BioPlex,STRINGDB
CDKL1
Tchem
Family:  Kinase
Novelty:  0.110338
p_int:  0.998719609
p_ni:  2.1e-8
p_wrong:  0.00128037
Score:  0.828
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.997944712
p_ni:  0.002055221
p_wrong:  6.7e-8
Data Source:  BioPlex
HSP90AA5P
Tdark
p_int:  0.995948168
p_ni:  0.004051832
Data Source:  BioPlex
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.986115059
p_ni:  0.013884941
Score:  0.532
Data Source:  BioPlex,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.98396318
p_ni:  0.01603682
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
p_int:  0.891724501
p_ni:  0.108275499
Score:  0.173
Data Source:  BioPlex,STRINGDB
TMEM138
Tdark
Novelty:  0.40357932
Score:  0.624
Data Source:  STRINGDB
GPATCH11
Tdark
Novelty:  0.86338046
Score:  0.522
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 4
VGNC:190
735724
Macaque
cyclin dependent kinase like 4
713846
Mouse
MGI:3587025
381113
Dog
cyclin dependent kinase like 4
VGNC:39066
608890
Horse
cyclin dependent kinase like 4
VGNC:16361
100053838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 4
Macaque
cyclin dependent kinase like 4
Mouse
Dog
cyclin dependent kinase like 4
Horse
cyclin dependent kinase like 4
Publication Statistics
PubMed Score 0.60
PubMed score by year
PubTator Score 1.00
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title