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Tchem
CDKL1
Cyclin-dependent kinase-like 1

Protein Summary
Description
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases that accumulates primarily in the nucleus. [provided by RefSeq, Nov 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395834
  • ENSP00000379176
  • ENSG00000100490

Symbol
  • P42
  • KKIALRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
protein domain
0.73
tissue sample
0.63
disease perturbation
0.62
histone modification site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.64   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.64   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (30)
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.9999381
p_ni:  0.0000619
Score:  0.392
Data Source:  BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int:  0.999856537
p_ni:  0.000143463
Data Source:  BioPlex
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.998869104
p_ni:  0.001130896
Score:  0.447
Data Source:  BioPlex,STRINGDB
CDKL4
Tdark
Family:  Kinase
Novelty:  1.22012755
p_int:  0.998719609
p_ni:  2.1e-8
p_wrong:  0.00128037
Score:  0.828
Data Source:  BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int:  0.992094484
p_ni:  0.007889574
p_wrong:  0.000015942
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.971659132
p_ni:  0.028330538
p_wrong:  0.00001033
Data Source:  BioPlex
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.908459719
p_ni:  0.091540277
p_wrong:  4e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
p_int:  0.833538264
p_ni:  0.166461736
Data Source:  BioPlex
SUPT5H
Tbio
Novelty:  0.00775042
p_int:  0.753392462
p_ni:  0.246607538
Score:  0.239
Data Source:  BioPlex,STRINGDB
TMEM218
Tdark
Novelty:  0.76457166
Score:  0.771
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
77.3
serum alanine aminotransferase measurement
1
1
1
77
red blood cell density measurement
1
1
1
71.9
body fat distribution
2
1
5
70.2
sex hormone-binding globulin measurement
2
1
2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
77.3
serum alanine aminotransferase measurement
1
77
red blood cell density measurement
1
71.9
body fat distribution
5
70.2
sex hormone-binding globulin measurement
2
66.3
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 1
VGNC:7437
100610829
Macaque
cyclin dependent kinase like 1
705975
Mouse
MGI:1918341
71091
Rat
RGD:1305080
314198
Dog
cyclin dependent kinase like 1
VGNC:39064
480317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase like 1
Macaque
cyclin dependent kinase like 1
Mouse
Rat
Dog
cyclin dependent kinase like 1
Publication Statistics
PubMed Score 11.64
PubMed score by year
PubTator Score 31.75
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title