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Tbio
CDKAL1
Threonylcarbamoyladenosine tRNA methylthiotransferase

Protein Summary
Description
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274695
  • ENSP00000274695
  • ENSG00000145996
  • ENST00000378610
  • ENSP00000367873
  • ENST00000613575
  • ENSP00000481755
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.99
virus perturbation
0.9
histone modification site profile
0.8
phenotype
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.13   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.13   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
MMS19
Tbio
Novelty:  0.01978769
p_int:  0.964107686
p_ni:  0.035892314
Score:  0.86
Data Source:  BioPlex,STRINGDB
TTYH3
Tbio
Family:  IC
Novelty:  0.21747247
p_int:  0.96030617
p_ni:  0.039693829
p_wrong:  2e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
BPIFB1
Tbio
Novelty:  0.03980683
p_int:  0.945121079
p_ni:  0.054016645
p_wrong:  0.000862276
Score:  0.211
Data Source:  BioPlex,STRINGDB
DNM1
Tbio
Novelty:  0.00319082
p_int:  0.877623661
p_ni:  0.122376339
Score:  0.605
Data Source:  BioPlex,STRINGDB
CIAO1
Tbio
Novelty:  0.03999673
p_int:  0.856907872
p_ni:  0.1430916
p_wrong:  5.28e-7
Score:  0.75
Data Source:  BioPlex,STRINGDB
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.809658679
p_ni:  0.190341208
p_wrong:  1.14e-7
Score:  0.192
Data Source:  BioPlex,STRINGDB
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.804885116
p_ni:  0.195114884
Score:  0.313
Data Source:  BioPlex,STRINGDB
TYW1B
Tdark
Family:  Enzyme
Novelty:  0.86504466
p_int:  0.761555332
p_ni:  0.012416187
p_wrong:  0.226028481
Score:  0.594
Data Source:  BioPlex,STRINGDB
IGF2BP2
Tbio
Novelty:  0.0105554
Score:  0.89
Data Source:  STRINGDB
TCF7L2
Tbio
Family:  TF
Novelty:  0.00178694
Score:  0.867
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
23
14
3
1.2
99.8
HbA1c measurement
6
6
6
96.2
birth weight
4
3
4
95.2
body mass index
7
6
7
3.4
94.8
glucose measurement
3
3
3
88.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.2
99.8
HbA1c measurement
6
96.2
birth weight
4
95.2
body mass index
7
3.4
94.8
glucose measurement
3
88.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 1 like 1
VGNC:7167
747778
Macaque
CDK5 regulatory subunit associated protein 1 like 1
706409
Mouse
MGI:1921765
68916
Dog
CDK5 regulatory subunit associated protein 1 like 1
VGNC:39063
488240
Horse
CDK5 regulatory subunit associated protein 1 like 1
VGNC:16358
100052309
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 1 like 1
Macaque
CDK5 regulatory subunit associated protein 1 like 1
Mouse
Dog
CDK5 regulatory subunit associated protein 1 like 1
Horse
CDK5 regulatory subunit associated protein 1 like 1
Publication Statistics
PubMed Score 118.13
PubMed score by year
PubTator Score 84.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title