Protein Summary
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modificatio ...more
- ENST00000373264
- ENSP00000362361
- ENSG00000136807
- CDC2L4
- TAK
- TAK
- C-2k
- CTK1
- CDC2L4
- PITALRE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
molecular function | 0.99 | ||
biological process | 0.98 | ||
protein complex | 0.95 | ||
pathway | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 524.17 (req: < 5)
Gene RIFs: 120 (req: <= 3)
Antibodies: 503 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 524.17 (req: >= 5)
Gene RIFs: 120 (req: > 3)
Antibodies: 503 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 38
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 253
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (253)
Protein-Protein Interactions (298)
HEXIM1
Novelty: 0.0142443
p_int: 0.999999816
p_ni: 1.84e-7
Score: 0.98
Data Source: BioPlex,STRINGDB
CCNT1
Novelty: 0.00526848
p_int: 0.999999749
p_ni: 2.51e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
HEXIM2
Novelty: 0.14814693
p_int: 0.999999569
p_ni: 4.31e-7
Score: 0.953
Data Source: BioPlex,STRINGDB
CCNT2
Novelty: 0.04593314
p_int: 0.99999954
p_ni: 4.6e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AFF4
Family: TF
Novelty: 0.02113896
p_int: 0.999999437
p_ni: 5.63e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
AFF1
Family: TF
Novelty: 0.00094358
p_int: 0.999997628
p_ni: 0.000001246
p_wrong: 0.000001126
Score: 0.875
Data Source: BioPlex,STRINGDB
FKBP5
Family: Enzyme
Novelty: 0.00214511
p_int: 0.999990428
p_ni: 0.000009572
Score: 0.416
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (60)
Reactome (33)
KEGG (1)
PathwayCommons (8)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | ESR-mediated signaling | ||||
Reactome | Estrogen-dependent gene expression | ||||
Reactome | Formation of HIV elongation complex in the absence of HIV Tat | ||||
Reactome | Formation of HIV-1 elongation complex containing HIV-1 Tat | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Disease | ||||
ESR-mediated signaling | ||||
Estrogen-dependent gene expression | ||||
Formation of HIV elongation complex in the absence of HIV Tat | ||||
Formation of HIV-1 elongation complex containing HIV-1 Tat | ||||
Viral Interactions (0)
Gene Ontology Terms (48)
Functions (15)
Components (10)
Processes (23)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 3 | 3 | 93.9 | |||||
hematocrit | 3 | 2 | 3 | 86.8 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 72.8 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 54.4 | |||||
granulocyte percentage of myeloid white cells | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 93.9 | |||||
hematocrit | 3 | 86.8 | |||||
monocyte percentage of leukocytes | 2 | 72.8 | |||||
neutrophil percentage of leukocytes | 1 | 54.4 | |||||
granulocyte percentage of myeloid white cells | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase 9 | VGNC:8807 | 464755 | |||||
Mouse | MGI:1328368 | 107951 | ||||||
Rat | RGD:1359638 | 362110 | ||||||
Dog | cyclin dependent kinase 9 | VGNC:39062 | 100855805 | |||||
Horse | cyclin dependent kinase 9 | VGNC:16357 | 100070437 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cyclin dependent kinase 9 | |||||
Horse | cyclin dependent kinase 9 | |||||
Publication Statistics
PubMed Score 524.17
PubMed score by year
PubTator Score 428.30
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (257)
GeneRif Annotations (120)
Items per page:
0 of 0
PMID | Year | Title |
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