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Tclin
CDK6
Cyclin-dependent kinase 6

Protein Summary
Description
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents my ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265734
  • ENSP00000265734
  • ENSG00000105810
  • ENST00000424848
  • ENSP00000397087

Symbol
  • CDKN6
  • MCPH12
  • PLSTIRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.97
molecular function
0.95
biological process
0.88
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.56   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 902   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.56   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 902   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 227
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (298)
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDKN2B
Tbio
Family:  Enzyme
Novelty:  0.00166614
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
EIF2AK1
Tchem
Family:  Kinase
Novelty:  0.01207075
p_int:  0.999999735
p_ni:  2.47e-7
p_wrong:  1.8e-8
Score:  0.283
Data Source:  BioPlex,STRINGDB
CCNT2
Tbio
Novelty:  0.04593314
p_int:  0.999964278
p_ni:  0.000035722
Score:  0.856
Data Source:  BioPlex,STRINGDB
CDKN2D
Tbio
Family:  Enzyme
Novelty:  0.01445471
p_int:  0.999890392
p_ni:  0.000109608
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
p_int:  0.999615234
p_ni:  0.000384766
Score:  0.869
Data Source:  BioPlex,STRINGDB
CDKN1C
Tbio
Family:  Enzyme
Novelty:  0.00220485
p_int:  0.999318414
p_ni:  0.0006517
p_wrong:  0.000029886
Score:  0.989
Data Source:  BioPlex,STRINGDB
MCF2L2
Tbio
Novelty:  0.0545344
p_int:  0.994552095
p_ni:  0.005447905
Score:  0.228
Data Source:  BioPlex,STRINGDB
PAK4
Tchem
Family:  Kinase
Novelty:  0.0068821
p_int:  0.985539508
p_ni:  0.014460486
p_wrong:  5e-9
Score:  0.426
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (75)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
8
5
12
99
neutrophil count
5
4
8
98.6
body height
6
5
6
5.8
98.5
basophil count
3
3
5
97.8
BMI-adjusted hip circumference
3
23
29
97.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
12
99
neutrophil count
8
98.6
body height
6
5.8
98.5
basophil count
5
97.8
BMI-adjusted hip circumference
29
97.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 6
VGNC:13637
746968
Macaque
cyclin dependent kinase 6
701822
Mouse
MGI:1277162
12571
Rat
RGD:621121
114483
Dog
cyclin dependent kinase 6
VGNC:54756
609920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 6
Macaque
cyclin dependent kinase 6
Mouse
Rat
Dog
cyclin dependent kinase 6
Publication Statistics
PubMed Score 791.56
PubMed score by year
PubTator Score 860.48
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title